An arbitrary waveform magnetic nanoparticle relaxometer with an asymmetrical  three-section gradiometric receive coil

Can Barış TOP

doi:https://doi.org/10.3906/elk-1907-201

Makale detayları

An arbitrary waveform magnetic nanoparticle relaxometer with an asymmetrical three-section gradiometric receive coil

Yazarlar:

Can Barış TOP

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Electrical Engineering and Computer Science 2020 Vol.28 Issue 3, pp.1344-1354

Belge Tipi:

Makale

Yayın Tarihi:

4/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000733097

Sıklık:

İki Aylık

eISSN:

1303-6203

pISSN:

1300-0632

DOI:

https://doi.org/10.3906/elk-1907-201

Özet:

 

Magnetic nanoparticles  MNPs  have a wide range of clinical applications for imaging, therapy, and biosensing.  Superparamagnetic MNPs can be directly visualized with high spatiotemporal resolution using the magnetic particle  imaging  MPI  modality. The image resolution of MPI depends on the relaxation properties of the MNPs. Therefore,  characterization of MNP response under alternating magnetic field excitation is necessary to predict MPI imaging  performance and develop optimized MNPs. Biosensing applications also make use of the change in the relaxation  response of MNPs after binding to a target agent. As MNP relaxation properties change with temperature and  viscosity, noninvasive probing of these microenvironmental properties is possible. In this work, we present an untuned  relaxometer to measure the relaxation properties of the MNPs in a wide frequency and amplitude range. The developed  relaxometer can produce above 80 mTpp magnetic field at up to 60 kHz frequency, and above 14 mTpp at up to  150 kHz frequency. An asymmetrical three-section gradiometer receive coil is used to cancel the direct coupled signal  from the transmit coil. The position of one of the receive coil sections is manually tuned using a rotating knob for  improved decoupling. The tuning coil section has a lower number of turns compared to the other sections to decrease  the sensitivity to mechanical movement. By tuning the knob, the transmit-receive coupling can be decreased below ?80 dB. We analyzed the x-space image resolution, harmonic levels, and effect of the number of used harmonics on the  resolution for two different commercially available superparamagnetic iron oxide MNPs  Perimag and Synomag-D  in a  multifrequency/multiamplitude measurement scheme. The magnetization properties of MNPs for arbitrary waveforms  can be measured efficiently using the developed relaxometer.

Makale detayları

An arbitrary waveform magnetic nanoparticle relaxometer with an asymmetrical three-section gradiometric receive coil

Yazarlar: Can Barış TOP

Yayıncı: TUBITAK

Dergi: Turkish Journal of Electrical Engineering and Computer Science 2020 Vol.28 Issue 3, pp.1344-1354

Belge Tipi: Makale

Yayın Tarihi: 4/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000733097

Sıklık: İki Aylık

eISSN: 1303-6203

pISSN: 1300-0632

DOI: https://doi.org/10.3906/elk-1907-201

Sayı

Yazarlar:

Can Barış TOP

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Electrical Engineering and Computer Science 2020 Vol.28 Issue 3, pp.1344-1354

Belge Tipi:

Makale

Yayın Tarihi:

4/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000733097

Sıklık:

İki Aylık

eISSN:

1303-6203

pISSN:

1300-0632

DOI:

https://doi.org/10.3906/elk-1907-201