The relationship between triglyceride/high-density lipoprotein cholesterol ratio and the functional significance of coronary lesions

Can Özkan

Makale detayları

The relationship between triglyceride/high-density lipoprotein cholesterol ratio and the functional significance of coronary lesions

Yazarlar:

Can Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 3, pp.149-154

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001321073

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: Have shown that triglycerides TG are an independent risk factor for cardiovascular disease CVD. Dyslipidemia characterized by low high-density lipoprotein cholesterol HDL-C has been shown to be associated with symptoms of coronary artery disease CAD. In studies, the TGHDL-C ratio has been found to be strongly associated with parameters indicative of the severity of coronary disease. In this study, we aimed to investigate whether the TGHDL-C ratio is associated with the functional significance of moderate coronary artery lesions. Methods: A total of 102 consecutive patients, 72 male and 30 female, who underwent measurement of fractional flow reserve FFR due to moderate coronary stenosis quantitative coronary analysis 40-70 on angiography were included in the study. An FFR value 0.80 was accepted for hemodynamic significance. Results: Among the 102 patients included in the study, it was determined that 52 50.9 had significant functional stenosis. Left ventricular ejection fraction of Group II was lower than Group I 60 55-62.5 vs. 5550-60, p0.006. The male patient ratio was higher in Group II, but the difference between the two groups was not significant 68 and 77, respectively, p0.072. Univariate and multivariate logistic regression analysis showed that TGHDL-C OR1.278, 95 CI1.078-1.514, p0.005 was an independent determinant of significant functional stenosis. ROC analysis revealed that the TGHDL-C value was 3.89 and provided 64 specificity and 61.5 sensitivity in predicting hemodynamically significant coronary artery stenosis. Conclusion: Elevated TGHDL-C values are associated with the functional significance of angiographically moderate coronary artery stenosis.

 Aims: Have shown that triglycerides TG are an independent risk factor for cardiovascular disease CVD. Dyslipidemia characterized by low high-density lipoprotein cholesterol HDL-C has been shown to be associated with symptoms of coronary artery disease CAD. In studies, the TGHDL-C ratio has been found to be strongly associated with parameters indicative of the severity of coronary disease. In this study, we aimed to investigate whether the TGHDL-C ratio is associated with the functional significance of moderate coronary artery lesions. Methods: A total of 102 consecutive patients, 72 male and 30 female, who underwent measurement of fractional flow reserve FFR due to moderate coronary stenosis quantitative coronary analysis 40-70 on angiography were included in the study. An FFR value 0.80 was accepted for hemodynamic significance. Results: Among the 102 patients included in the study, it was determined that 52 50.9 had significant functional stenosis. Left ventricular ejection fraction of Group II was lower than Group I 60 55-62.5 vs. 5550-60, p0.006. The male patient ratio was higher in Group II, but the difference between the two groups was not significant 68 and 77, respectively, p0.072. Univariate and multivariate logistic regression analysis showed that TGHDL-C OR1.278, 95 CI1.078-1.514, p0.005 was an independent determinant of significant functional stenosis. ROC analysis revealed that the TGHDL-C value was 3.89 and provided 64 specificity and 61.5 sensitivity in predicting hemodynamically significant coronary artery stenosis. Conclusion: Elevated TGHDL-C values are associated with the functional significance of angiographically moderate coronary artery stenosis.

 Aims: Have shown that triglycerides TG are an independent risk factor for cardiovascular disease CVD. Dyslipidemia characterized by low high-density lipoprotein cholesterol HDL-C has been shown to be associated with symptoms of coronary artery disease CAD. In studies, the TGHDL-C ratio has been found to be strongly associated with parameters indicative of the severity of coronary disease. In this study, we aimed to investigate whether the TGHDL-C ratio is associated with the functional significance of moderate coronary artery lesions. Methods: A total of 102 consecutive patients, 72 male and 30 female, who underwent measurement of fractional flow reserve FFR due to moderate coronary stenosis quantitative coronary analysis 40-70 on angiography were included in the study. An FFR value 0.80 was accepted for hemodynamic significance. Results: Among the 102 patients included in the study, it was determined that 52 50.9 had significant functional stenosis. Left ventricular ejection fraction of Group II was lower than Group I 60 55-62.5 vs. 5550-60, p0.006. The male patient ratio was higher in Group II, but the difference between the two groups was not significant 68 and 77, respectively, p0.072. Univariate and multivariate logistic regression analysis showed that TGHDL-C OR1.278, 95 CI1.078-1.514, p0.005 was an independent determinant of significant functional stenosis. ROC analysis revealed that the TGHDL-C value was 3.89 and provided 64 specificity and 61.5 sensitivity in predicting hemodynamically significant coronary artery stenosis. Conclusion: Elevated TGHDL-C values are associated with the functional significance of angiographically moderate coronary artery stenosis.

 AMAÇ Yapılan çalışmalarda trigliseridlerin TG kardiyovasküler hastalık KVH için bağımsız bir risk faktörü olduğunu gösterilmektedir. Düşük, yüksek yoğunluklu lipoprotein kolesterel HDL-K ile karakterize dislipideminin KAH belirtileriyle ilişkili olduğu gösterilmiştir. Yapılan çalışmalarda TGHDL-K oranının, koroner hastalığın derecesi ile güçlü şekilde ilişkili parametreler olduğu saptanmıştır Bu çalışmada, TGHDL-K oranının orta koroner arter lezyonlarının fonksiyonel önemi ile ilişkili olup olmadığını araştırmayı amaçladık. GEREÇ ve YÖNTEM Anjiyografik olarak orta derecede koroner darlık kantitatif koroner analizde 40-70 nedeniyle fraksiyonel akım rezervi FAR ölçümü yapılan 72i erkek, 30sı kadın olmak üzere 102 ardışık hasta çalışmaya dahil edildi. FAR değerinin  0.80 olması hemodinamik anlamlılık için kabul edildi. BULGULAR Çalışmaya dahil edilen 102 hasta arasında, 52sinin 50.9 önemli fonksiyonel darlık olduğu belirlendi. Grup IInin sol ventrikül ejeksiyon fraksiyonu, grup Ie göre daha düşüktü 60 55-62.5 vs. 5550-60, p  0.006. Grup IIde erkek hasta oranı daha yüksekti ancak iki grup arasındaki fark anlamlı değildi sırasıyla 68 ve 77, p  0.072. Tek değişkenli ve çoklu lojistik regresyon analizi, TGHDL-Knin OR  1.278, 95 CI  1.078-1.514, p  0.005 önemli fonksiyonel darlığın bağımsız belirleyicilerinden olduğunu gösterdi. ROC analizi, TGHDL-K değerinin 3.89 olduğunu ve hemodinamik olarak önemli koroner arter darlığını tahmin etmede 64 spesifiklik ve 61.5 duyarlılık sağladığını ortaya koydu. SONUÇ Yükselmiş TGHDL-K değerleri, anjiyografik olarak orta düzey koroner arter darlığının fonksiyonel önemi ile ilişkilendirilmiştir.

Makale detayları

The relationship between triglyceride/high-density lipoprotein cholesterol ratio and the functional significance of coronary lesions

Yazarlar:

Can Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 3, pp.149-154

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001321073

pISSN:

2717-7505

Coronary Artery Disease

Triglyceride

Fractional Flow Reserve

HDL-CKoroner Arter Hastalığı

Trigliserid

Fraksiyonel Akım Rezervi

Sayı

Makale detayları

The relationship between triglyceride/high-density lipoprotein cholesterol ratio and the functional significance of coronary lesions

Yazarlar: Can Özkan

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kardiyoloji

Dergi: Journal of Medicine and Palliative Care Vol.5 Issue 3, pp.149-154

Belge Tipi: Makale

Yayın Tarihi: 6/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001321073

pISSN: 2717-7505

Coronary Artery Disease

Triglyceride

Fractional Flow Reserve

HDL-CKoroner Arter Hastalığı

Trigliserid

Fraksiyonel Akım Rezervi

Sayı

Yazarlar:

Can Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 3, pp.149-154

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001321073

pISSN:

2717-7505