Synthesis and Characterization of Several Mannich Bases Derived from 2-(4-methylpiperazin-1-yl)acetohydrazide

Yıldız Uygun Cebecı

Makale detayları

Synthesis and Characterization of Several Mannich Bases Derived from 2-(4-methylpiperazin-1-yl)acetohydrazide

Yazarlar:

Yıldız Uygun Cebecı

Yayıncı:

Bitlis Eren University

Ana Başlıklar:

Organic Chemical Synthesis

Dergi:

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.13 Issue 4, pp.979-987

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001336475

pISSN:

2147-3129

Anahtar kelimeler:

Özet:

 This study explores the transformation of 2-4-methylpiperazin-1-ylacetohydrazide 1 through its reaction with phenylisothiocyanate 2, resulting in the formation of a novel urea derivative 3. The synthesis involves an intramolecular ring closure, where the hydrazide functionality plays a crucial role, leading to the formation of a 1,2,4-triazole structure. The journey continues as the 1,2,4-triazole derivative undergoes a Mannich reaction, leveraging its active methylene group. By reacting Compound 3 with formaldehyde and a selection of primary or secondary amines, a β-aminocarbonyl compound is synthesized, showcasing a significant molecular transformation. The structural elucidation of the synthesized compounds is carried out using a range of sophisticated analytical techniques, including mass spectrometry, infrared IR spectroscopy, and nuclear magnetic resonance NMR spectroscopy for both ¹H and ¹³C nuclei. These methods provide deep insights into the molecular architecture, enabling the determination of atomic connectivity and the identification of functional groups, thus confirming the integrity and structure of the synthesized molecules.

 This study explores the transformation of 2-4-methylpiperazin-1-ylacetohydrazide 1 through its reaction with phenylisothiocyanate 2, resulting in the formation of a novel urea derivative 3. The synthesis involves an intramolecular ring closure, where the hydrazide functionality plays a crucial role, leading to the formation of a 1,2,4-triazole structure. The journey continues as the 1,2,4-triazole derivative undergoes a Mannich reaction, leveraging its active methylene group. By reacting Compound 3 with formaldehyde and a selection of primary or secondary amines, a β-aminocarbonyl compound is synthesized, showcasing a significant molecular transformation. The structural elucidation of the synthesized compounds is carried out using a range of sophisticated analytical techniques, including mass spectrometry, infrared IR spectroscopy, and nuclear magnetic resonance NMR spectroscopy for both ¹H and ¹³C nuclei. These methods provide deep insights into the molecular architecture, enabling the determination of atomic connectivity and the identification of functional groups, thus confirming the integrity and structure of the synthesized molecules.

 This study explores the transformation of 2-4-methylpiperazin-1-ylacetohydrazide 1 through its reaction with phenylisothiocyanate 2, resulting in the formation of a novel urea derivative 3. The synthesis involves an intramolecular ring closure, where the hydrazide functionality plays a crucial role, leading to the formation of a 1,2,4-triazole structure. The journey continues as the 1,2,4-triazole derivative undergoes a Mannich reaction, leveraging its active methylene group. By reacting Compound 3 with formaldehyde and a selection of primary or secondary amines, a β-aminocarbonyl compound is synthesized, showcasing a significant molecular transformation. The structural elucidation of the synthesized compounds is carried out using a range of sophisticated analytical techniques, including mass spectrometry, infrared IR spectroscopy, and nuclear magnetic resonance NMR spectroscopy for both ¹H and ¹³C nuclei. These methods provide deep insights into the molecular architecture, enabling the determination of atomic connectivity and the identification of functional groups, thus confirming the integrity and structure of the synthesized molecules.

 This study explores the transformation of 2-4-methylpiperazin-1-ylacetohydrazide 1 through its reaction with phenylisothiocyanate 2, resulting in the formation of a novel urea derivative 3. The synthesis involves an intramolecular ring closure, where the hydrazide functionality plays a crucial role, leading to the formation of a 1,2,4-triazole structure. The journey continues as the 1,2,4-triazole derivative undergoes a Mannich reaction, leveraging its active methylene group. By reacting Compound 3 with formaldehyde and a selection of primary or secondary amines, a β-aminocarbonyl compound is synthesized, showcasing a significant molecular transformation. The structural elucidation of the synthesized compounds is carried out using a range of sophisticated analytical techniques, including mass spectrometry, infrared IR spectroscopy, and nuclear magnetic resonance NMR spectroscopy for both ¹H and ¹³C nuclei. These methods provide deep insights into the molecular architecture, enabling the determination of atomic connectivity and the identification of functional groups, thus confirming the integrity and structure of the synthesized molecules.

Makale detayları

Synthesis and Characterization of Several Mannich Bases Derived from 2-(4-methylpiperazin-1-yl)acetohydrazide

Yazarlar:

Yıldız Uygun Cebecı

Yayıncı:

Bitlis Eren University

Ana Başlıklar:

Organic Chemical Synthesis

Dergi:

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.13 Issue 4, pp.979-987

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001336475

pISSN:

2147-3129

Methylpiperazin

fluoroquinolone

mannich base

1,2,4-triazole

Sayı

Makale detayları

Synthesis and Characterization of Several Mannich Bases Derived from 2-(4-methylpiperazin-1-yl)acetohydrazide

Yazarlar: Yıldız Uygun Cebecı

Yayıncı: Bitlis Eren University

Ana Başlıklar: Organic Chemical Synthesis

Dergi: Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.13 Issue 4, pp.979-987

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001336475

pISSN: 2147-3129

Methylpiperazin

fluoroquinolone

mannich base

1,2,4-triazole

Sayı

Yazarlar:

Yıldız Uygun Cebecı

Yayıncı:

Bitlis Eren University

Ana Başlıklar:

Organic Chemical Synthesis

Dergi:

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi Vol.13 Issue 4, pp.979-987

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001336475

pISSN:

2147-3129