Factors affecting the prognosis of lymphatic recurrences in endometrial cancer

Akbar Ibrahimov; Aygun Hasanova; Fidan Novruzova

Makale detayları

Factors affecting the prognosis of lymphatic recurrences in endometrial cancer

Yazarlar:

Akbar Ibrahimov | Aygun Hasanova | Fidan Novruzova

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi | Tıp Eğitimi | Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Dicle Tıp Dergisi Vol.52 Issue 3, pp.599-608

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001358328

pISSN:

1300-2945

Anahtar kelimeler:

Özet:

 Objective: This study aimed to evaluate factors influencing prognosis and oncological outcomes in patients with endometrioid-type endometrial cancer EEC who developed isolated pelvic andor periaortic lymph node recurrence LNR after surgery. Methods: A retrospective analysis was conducted on 24 patients who underwent hysterectomy and salpingo-oophorectomy for EEC in our hospital between 2017 and 2024. Among these patients, lymphatic recurrence patterns were categorized as follows: isolated pelvic lymph node metastasis PLNM in 6 patients 25.0, isolated periaortic lymph node metastasis PALNM in 7 patients 29.2, and both PLNM and PALNM in 11 patients 45.8. Survival outcomes after recurrence were evaluated, with logistic regression analysis applied to identify factors affecting post-recurrence survival. Results: Post-recurrence survival 2 years was observed in 8 patients 33.3. Univariate analysis identified grade 3 tumors, deep myometrial invasion, disease-free survival DFS 18 months, and surgical resection of recurrence as significant factors influencing prognosis. However, multivariate analysis did not reveal any independent prognostic factors. Notably, grade 3 tumors and deep myometrial invasion were associated with poorer survival outcomes, while longer DFS 18 months and surgical resection of recurrence had a favorable impact on prognosis. Conclusion: In patients with EEC and isolated lymphatic recurrence, grade 3 tumors and deep myometrial invasion appear to negatively affect survival outcomes. A longer DFS 18 months and surgical resection of recurrence are important factors associated with improved prognosis. These findings highlight the need for individualized management strategies to optimize outcomes in this patient population.

 Objective: This study aimed to evaluate factors influencing prognosis and oncological outcomes in patients with endometrioid-type endometrial cancer EEC who developed isolated pelvic andor periaortic lymph node recurrence LNR after surgery. Methods: A retrospective analysis was conducted on 24 patients who underwent hysterectomy and salpingo-oophorectomy for EEC in our hospital between 2017 and 2024. Among these patients, lymphatic recurrence patterns were categorized as follows: isolated pelvic lymph node metastasis PLNM in 6 patients 25.0, isolated periaortic lymph node metastasis PALNM in 7 patients 29.2, and both PLNM and PALNM in 11 patients 45.8. Survival outcomes after recurrence were evaluated, with logistic regression analysis applied to identify factors affecting post-recurrence survival. Results: Post-recurrence survival 2 years was observed in 8 patients 33.3. Univariate analysis identified grade 3 tumors, deep myometrial invasion, disease-free survival DFS 18 months, and surgical resection of recurrence as significant factors influencing prognosis. However, multivariate analysis did not reveal any independent prognostic factors. Notably, grade 3 tumors and deep myometrial invasion were associated with poorer survival outcomes, while longer DFS 18 months and surgical resection of recurrence had a favorable impact on prognosis. Conclusion: In patients with EEC and isolated lymphatic recurrence, grade 3 tumors and deep myometrial invasion appear to negatively affect survival outcomes. A longer DFS 18 months and surgical resection of recurrence are important factors associated with improved prognosis. These findings highlight the need for individualized management strategies to optimize outcomes in this patient population.

 Objective: This study aimed to evaluate factors influencing prognosis and oncological outcomes in patients with endometrioid-type endometrial cancer EEC who developed isolated pelvic andor periaortic lymph node recurrence LNR after surgery. Methods: A retrospective analysis was conducted on 24 patients who underwent hysterectomy and salpingo-oophorectomy for EEC in our hospital between 2017 and 2024. Among these patients, lymphatic recurrence patterns were categorized as follows: isolated pelvic lymph node metastasis PLNM in 6 patients 25.0, isolated periaortic lymph node metastasis PALNM in 7 patients 29.2, and both PLNM and PALNM in 11 patients 45.8. Survival outcomes after recurrence were evaluated, with logistic regression analysis applied to identify factors affecting post-recurrence survival. Results: Post-recurrence survival 2 years was observed in 8 patients 33.3. Univariate analysis identified grade 3 tumors, deep myometrial invasion, disease-free survival DFS 18 months, and surgical resection of recurrence as significant factors influencing prognosis. However, multivariate analysis did not reveal any independent prognostic factors. Notably, grade 3 tumors and deep myometrial invasion were associated with poorer survival outcomes, while longer DFS 18 months and surgical resection of recurrence had a favorable impact on prognosis. Conclusion: In patients with EEC and isolated lymphatic recurrence, grade 3 tumors and deep myometrial invasion appear to negatively affect survival outcomes. A longer DFS 18 months and surgical resection of recurrence are important factors associated with improved prognosis. These findings highlight the need for individualized management strategies to optimize outcomes in this patient population.

 Amaç: Bu çalışma, cerrahi sonrası izole pelvik veveya periaortik lenf nodu rekürrensi LNR gelişen endometrioid tip endometrial kanser ETEK hastalarında prognozu ve onkolojik sonuçları etkileyen faktörleri değerlendirmeyi amaçlamıştır. Yöntemler: Hastanemizde 2017-2024 yılları arasında ETEK nedeniyle histerektomi ve salpingooferektomi yapılan 24 hasta üzerinde retrospektif bir analiz gerçekleştirildi. Bu hastalarda lenfatik rekürrens paternleri şu şekilde kategorize edildi: 6 hastada 25,0 izole pelvik lenf nodu metastazı PLNM, 7 hastada 29,2 izole periaortik lenf nodu metastazı PALNM ve 11 hastada 45,8 hem PLNM hem de PALNM. Rekürrens sonrası sağkalım sonuçları değerlendirildi ve rekürrens sonrası sağkalımı etkileyen faktörleri belirlemek için lojistik regresyon analizi uygulandı. Bulgular: Rekürrens sonrası sağkalımı 2 yıl olan 8 hasta 33,3 tespit edildi. Tek değişkenli analizde grade 3 tümörler, derin miyometriyal invazyon, hastalıksız sağkalım süresinin DFS 18 ay olması ve rekürrens cerrahi rezeksiyonu prognozu etkileyen önemli faktörler olarak belirlendi. Ancak çok değişkenli analizde bağımsız prognostik faktörler bulunamadı. Özellikle, grade 3 tümörler ve derin miyometriyal invazyon daha kötü sağkalım sonuçları ile ilişkilendirilirken, uzun DFS süresi 18 ay ve rekürrens cerrahisi prognoz üzerinde olumlu bir etkiye sahipti. Sonuç: ETEK ve izole lenfatik rekürrensi olan hastalarda, grade 3 tümörler ve derin miyometriyal invazyon sağkalım sonuçlarını olumsuz etkileyebilir. Uzun DFS süresi 18 ay ve rekürrens cerrahisi prognozla ilişkili önemli faktörlerdir. Bu bulgular, bu hasta popülasyonunda sonuçları optimize etmek için bireyselleştirilmiş yönetim stratejilerinin önemini vurgulamaktadır.

Makale detayları

Factors affecting the prognosis of lymphatic recurrences in endometrial cancer

Yazarlar:

Akbar Ibrahimov | Aygun Hasanova | Fidan Novruzova

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi | Tıp Eğitimi | Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Dicle Tıp Dergisi Vol.52 Issue 3, pp.599-608

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001358328

pISSN:

1300-2945

recurrence

surgery

endometrial cancer

lymph node.endometrial kanser

lenf nodu

nüks

cerrahi

Sayı

Makale detayları

Yazarlar: Akbar Ibrahimov | Aygun Hasanova | Fidan Novruzova

Yayıncı: Dicle University

Ana Başlıklar: Sağlık Kurumları Yönetimi | Tıp Eğitimi | Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: Dicle Tıp Dergisi Vol.52 Issue 3, pp.599-608

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001358328

pISSN: 1300-2945

Sayı

Yazarlar:

Akbar Ibrahimov | Aygun Hasanova | Fidan Novruzova

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık Kurumları Yönetimi | Tıp Eğitimi | Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

Dicle Tıp Dergisi Vol.52 Issue 3, pp.599-608

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001358328

pISSN:

1300-2945