DOES PUERARIN HAVE GENOTOXIC PROPERTIES on MAMMALIAN CELL LINES?

Merve BACANLI; Hatice Gül ANLAR; A. Ahmet BAŞARAN; Nurşen BAŞARAN

Makale detayları

DOES PUERARIN HAVE GENOTOXIC PROPERTIES on MAMMALIAN CELL LINES?

Yazarlar:

Merve BACANLI | Hatice Gül ANLAR | A. Ahmet BAŞARAN | Nurşen BAŞARAN

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-128

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000835314

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711

Özet:

 


It is well known
that free oxygen radicals play important role in the pathogenesis of chronic
disorders such as cancer, diabetes, cardiovascular and neurological diseases.
Recent interest in plant phenolics has increased because of their protective
effects against free oxygen radicals. Puerarin
[7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4-one 8-(β-D-glucopyranozid)],
isoflavone glycoside, primarily derived from Ge-gen (Pueraria lobata, Radix
Puerariae). This medicinal plant is commonly used in Chinese folk medicine.
Pueraria lobata has been used against alcohol dependency, hypertension, fever,
headache, diarrhea and eye disorders. Phytoestrogenic activity of puerarin due
to its isoflavone structure is very important in woman diseases. In the present
study genotoxic/antigenotoxic effects of puerarin were evaluated by alkaline Comet
assay in human peripheral blood lymphocytes and Chinese hamster lung fibroblast
cells (V79). Cells were treated with 1, 5, 10, 25 and 50 µM puerarin, hydrogen
peroxide (H2O2) was used as the positive control.
According to the study, puerarin did not cause DNA damage. DNA damage was
significantly lower in the puerarin + H2O2 treated group
when compared to positive control. It seems that puerarin might have a role in
the prevention of DNA damage.

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Makale detayları

DOES PUERARIN HAVE GENOTOXIC PROPERTIES on MAMMALIAN CELL LINES?

Yazarlar: Merve BACANLI | Hatice Gül ANLAR | A. Ahmet BAŞARAN | Nurşen BAŞARAN

Yayıncı: Engin TUTKUN

Dergi: The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-128

Belge Tipi: Makale

Yayın Tarihi: 2/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000835314

Sıklık: Üç Aylık

eISSN: 2149-4711

pISSN: 2149-4711

Sayı

Yazarlar:

Merve BACANLI | Hatice Gül ANLAR | A. Ahmet BAŞARAN | Nurşen BAŞARAN

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-128

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000835314

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711