Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat's brain and spleen

N.A.

Makale detayları

Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat's brain and spleen

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1323-1330

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347551

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Carbon tetrachloride CCl4 causes tissues damage by inducing a state of oxidative stress. This research was arranged to evaluate the role of L-glutamic acid L-Glu against oxidative stress induced by CCl4 in brain and spleen tissues of rats. Antioxidant profiles were evaluated by estimating the activities of antioxidant enzymes; superoxide dismutase SOD, catalase CAT, glutathione-S-transferase GST, glutathione peroxidase GPx, glutathione reductase GR and reduced glutathione GSH. In addition to this, the lipid peroxidation products content TBARS and LOOH was monitored. Rats were divided into three groups: two experimental CCl4, CCl4L-Glu and Control. The rats of CCl4 group were treated with CCl4 only, CCl4L-Glu group was treated with CCl4 and L-Glu. Administration of CCl4 reduced the antioxidant enzymes activity in the spleen and brain tissues of rats. Co-treatment of L-Glu restored the activities of antioxidant enzymes GPx brain, GST spleen, GR spleen, brain compared to control and CCl4 experimental group of animals. Increased spleen TBARS content was observed in rats treated with CCl4. But this index didnt change in the CCl4L-Glu group, which additionally received L-Glu. Results of the present study revealed that LGlu could protect the brain and spleen tissues against oxidative stress induced by CCl4.

 Carbon tetrachloride CCl4 causes tissues damage by inducing a state of oxidative stress. This research was arranged to evaluate the role of L-glutamic acid L-Glu against oxidative stress induced by CCl4 in brain and spleen tissues of rats. Antioxidant profiles were evaluated by estimating the activities of antioxidant enzymes; superoxide dismutase SOD, catalase CAT, glutathione-S-transferase GST, glutathione peroxidase GPx, glutathione reductase GR and reduced glutathione GSH. In addition to this, the lipid peroxidation products content TBARS and LOOH was monitored. Rats were divided into three groups: two experimental CCl4, CCl4L-Glu and Control. The rats of CCl4 group were treated with CCl4 only, CCl4L-Glu group was treated with CCl4 and L-Glu. Administration of CCl4 reduced the antioxidant enzymes activity in the spleen and brain tissues of rats. Co-treatment of L-Glu restored the activities of antioxidant enzymes GPx brain, GST spleen, GR spleen, brain compared to control and CCl4 experimental group of animals. Increased spleen TBARS content was observed in rats treated with CCl4. But this index didnt change in the CCl4L-Glu group, which additionally received L-Glu. Results of the present study revealed that LGlu could protect the brain and spleen tissues against oxidative stress induced by CCl4.

 Carbon tetrachloride CCl4 causes tissues damage by inducing a state of oxidative stress. This research was arranged to evaluate the role of L-glutamic acid L-Glu against oxidative stress induced by CCl4 in brain and spleen tissues of rats. Antioxidant profiles were evaluated by estimating the activities of antioxidant enzymes; superoxide dismutase SOD, catalase CAT, glutathione-S-transferase GST, glutathione peroxidase GPx, glutathione reductase GR and reduced glutathione GSH. In addition to this, the lipid peroxidation products content TBARS and LOOH was monitored. Rats were divided into three groups: two experimental CCl4, CCl4L-Glu and Control. The rats of CCl4 group were treated with CCl4 only, CCl4L-Glu group was treated with CCl4 and L-Glu. Administration of CCl4 reduced the antioxidant enzymes activity in the spleen and brain tissues of rats. Co-treatment of L-Glu restored the activities of antioxidant enzymes GPx brain, GST spleen, GR spleen, brain compared to control and CCl4 experimental group of animals. Increased spleen TBARS content was observed in rats treated with CCl4. But this index didnt change in the CCl4L-Glu group, which additionally received L-Glu. Results of the present study revealed that LGlu could protect the brain and spleen tissues against oxidative stress induced by CCl4.

 Carbon tetrachloride CCl4 causes tissues damage by inducing a state of oxidative stress. This research was arranged to evaluate the role of L-glutamic acid L-Glu against oxidative stress induced by CCl4 in brain and spleen tissues of rats. Antioxidant profiles were evaluated by estimating the activities of antioxidant enzymes; superoxide dismutase SOD, catalase CAT, glutathione-S-transferase GST, glutathione peroxidase GPx, glutathione reductase GR and reduced glutathione GSH. In addition to this, the lipid peroxidation products content TBARS and LOOH was monitored. Rats were divided into three groups: two experimental CCl4, CCl4L-Glu and Control. The rats of CCl4 group were treated with CCl4 only, CCl4L-Glu group was treated with CCl4 and L-Glu. Administration of CCl4 reduced the antioxidant enzymes activity in the spleen and brain tissues of rats. Co-treatment of L-Glu restored the activities of antioxidant enzymes GPx brain, GST spleen, GR spleen, brain compared to control and CCl4 experimental group of animals. Increased spleen TBARS content was observed in rats treated with CCl4. But this index didnt change in the CCl4L-Glu group, which additionally received L-Glu. Results of the present study revealed that LGlu could protect the brain and spleen tissues against oxidative stress induced by CCl4.

Makale detayları

Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat's brain and spleen

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1323-1330

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347551

pISSN:

2630-6344

L-glutamic acid

carbon tetrachloride

antioxidant system

enzymes

oxidative stress

Sayı

Makale detayları

Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat's brain and spleen

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Sciences

Dergi: Journal of Research in Pharmacy Vol.26 Issue 5, pp.1323-1330

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347551

pISSN: 2630-6344

L-glutamic acid

carbon tetrachloride

antioxidant system

enzymes

oxidative stress

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1323-1330

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347551

pISSN:

2630-6344