Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats

Ayfer Beceren; Sezgin Aydemir; Esin Ak; Feriha Ercan; Göksel Şener

Makale detayları

Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats

Yazarlar:

Ayfer Beceren | Sezgin Aydemir | Esin Ak | Feriha Ercan | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1617-1625

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347863

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol RVT has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol RVT, a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups 8 animalsgroup as the control, radiation-early effects Rd-E, radiation-late effects Rd-L, and RVT-treated Rd-E Rd-ERVT and RVT-treated Rd-L Rd-LRVT groups. İonizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered 10 mgkgday immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd-L groups in the colon and rectum tissues. Additionally, light microscopic evaluations HE staining revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.

 Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol RVT has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol RVT, a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups 8 animalsgroup as the control, radiation-early effects Rd-E, radiation-late effects Rd-L, and RVT-treated Rd-E Rd-ERVT and RVT-treated Rd-L Rd-LRVT groups. İonizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered 10 mgkgday immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd-L groups in the colon and rectum tissues. Additionally, light microscopic evaluations HE staining revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.

 Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol RVT has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol RVT, a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups 8 animalsgroup as the control, radiation-early effects Rd-E, radiation-late effects Rd-L, and RVT-treated Rd-E Rd-ERVT and RVT-treated Rd-L Rd-LRVT groups. İonizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered 10 mgkgday immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd-L groups in the colon and rectum tissues. Additionally, light microscopic evaluations HE staining revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.

 Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol RVT has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol RVT, a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups 8 animalsgroup as the control, radiation-early effects Rd-E, radiation-late effects Rd-L, and RVT-treated Rd-E Rd-ERVT and RVT-treated Rd-L Rd-LRVT groups. İonizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered 10 mgkgday immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd-L groups in the colon and rectum tissues. Additionally, light microscopic evaluations HE staining revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.

Makale detayları

Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats

Yazarlar:

Ayfer Beceren | Sezgin Aydemir | Esin Ak | Feriha Ercan | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1617-1625

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347863

pISSN:

2630-6344

Resveratrol

early and late effect of radiation

pelvic radiation

radioprotection

oxidative stress

8-OHdG

Sayı

Makale detayları

Radioprotective effect of resveratrol for early and late ionizing radiation-induced damages on colon and rectum in rats

Yazarlar: Ayfer Beceren | Sezgin Aydemir | Esin Ak | Feriha Ercan | Göksel Şener

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Toxicology

Dergi: Journal of Research in Pharmacy Vol.27 Issue 4, pp.1617-1625

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347863

pISSN: 2630-6344

Resveratrol

early and late effect of radiation

pelvic radiation

radioprotection

oxidative stress

8-OHdG

Sayı

Yazarlar:

Ayfer Beceren | Sezgin Aydemir | Esin Ak | Feriha Ercan | Göksel Şener

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 4, pp.1617-1625

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347863

pISSN:

2630-6344