Relationship between PK2 and number of Kupffer cells during  the progression of liver fibrosis in patients with HBV

Xiao-qin LIU; Rong-rong WEI; Cheng-cheng WANG; Li-yu CHEN; Cong LIU; Kai LIU

Makale detayları

Relationship between PK2 and number of Kupffer cells during the progression of liver fibrosis in patients with HBV

Yazarlar:

Xiao-qin LIU | Rong-rong WEI | Cheng-cheng WANG | Li-yu CHEN | Cong LIU | Kai LIU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 1, pp.52-61

Belge Tipi:

Makale

Yayın Tarihi:

1/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750894

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: This study aimed to investigate the potential regulatory role of prokineticin 2 (PK2) in modulation of the number and function of Kupffer cells (KCs) during the progression of liver fibrosis in patients with hepatitis B virus (HBV).  Materials and methods: We obtained liver tissue sections from 200 patients with HBV undergoing surgical resection in our hospital between January 2013 and July 2016. Of these 200 tissue sections, 150 were fibrosis tissues and 50 were hepatocellular carcinoma tissues. Immunohistochemical evaluations were performed to assess the expression levels of CD68 and PK2 in the sections. The clinical parameters of these 200 patients were also analyzed.  Results: As a potential cytokine, PK2 was commonly expressed in KCs. In addition, a close correlation between PK2 and the number of KCs during the progression of liver fibrosis in patients with HBV was found in this study.  Conclusion: PK2 is expressed in KCs and participates in the progression of liver fibrosis after HBV infection. As a potential cytokine, PK2 modulates the number of KCs during fibrosis. Thus, PK2 most likely adjusts the number of M1 cells to modulate the role of KCs in the progression of liver fibrosis after HBV infection.

Makale detayları

Relationship between PK2 and number of Kupffer cells during the progression of liver fibrosis in patients with HBV

Yazarlar: Xiao-qin LIU | Rong-rong WEI | Cheng-cheng WANG | Li-yu CHEN | Cong LIU | Kai LIU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 1, pp.52-61

Belge Tipi: Makale

Yayın Tarihi: 1/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750894

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Xiao-qin LIU | Rong-rong WEI | Cheng-cheng WANG | Li-yu CHEN | Cong LIU | Kai LIU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 1, pp.52-61

Belge Tipi:

Makale

Yayın Tarihi:

1/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750894

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144