Early-onset versus late-onset fetal cerebral ventriculomegaly: Sonographic characteristics and neonatal outcomes

Ruken Dayanan; Ahmet Arif Filiz; Merve Ayas Özkan; Dilara Duygulu Bulan; Hatice Ayhan; Ecem Bakan; Gülşan Karabay; Şevki Çelen

Makale detayları

Early-onset versus late-onset fetal cerebral ventriculomegaly: Sonographic characteristics and neonatal outcomes

Yazarlar:

Ruken Dayanan | Ahmet Arif Filiz | Merve Ayas Özkan | Dilara Duygulu Bulan | Hatice Ayhan | Ecem Bakan | Gülşan Karabay | Şevki Çelen

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

The European Research Journal Vol.11 Issue 5, pp.885-895

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356987

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: This study aimed to compare the prenatal ultrasound characteristics, pregnancy outcomes, and neonatal prognosis of early- and late-onset fetal ventriculomegaly VM. Methods: A retrospective analysis was conducted on 102 pregnant women diagnosed with fetal VM, categorized into early-onset 24 weeks and late-onset 24 weeks groups. Maternal characteristics, ventricular dimensions, associated anomalies, pregnancy outcomes, and neonatal parameters were compared between the groups. Results: Early-onset VM was significantly associated with progressive ventricular enlargement, bilateral involvement, and a higher prevalence of additional anomalies detected via ultrasonography 70.4 vs. 29.2, P0.001 and Magnetic resonance imaging MRI 35.4 vs. 16.7, P0.030. Prenatal ultrasound findings differed significantly between the groups; early-onset VM cases more frequently exhibited bilateral 72.2 vs. 39.6, P0.002 and asymmetric 46.3 vs. 31.2, P0.037 ventricular enlargement, while late-onset VM was more commonly isolated 70.8 vs. 29.6, P0.001 and unilateral 60.4 vs. 27.8. Live birth rates were lower 55.6 vs. 85.4, P0.001, pregnancy termination rates were higher 44.4 vs. 14.6, P0.001 and chromosomal abnormalities were higher 16.7 vs. 8.3, P0.246 in early-onset cases. Additionally, Apgar scores at 1 and 5 minutes were significantly lower in the early-onset group P0.028 and P0.042, respectively. Conclusions: Early-onset VM is more frequently associated with ventricular progression and structural anomalies, leading to poorer pregnancy and neonatal outcomes. These findings highlight the importance of close prenatal monitoring, including detailed ultrasound, fetal MRI, and genetic evaluation, to guide clinical management and parental counseling. Future studies with long-term neurodevelopmental follow-up are needed to further refine risk stratification and optimize patient care.

 Objectives: This study aimed to compare the prenatal ultrasound characteristics, pregnancy outcomes, and neonatal prognosis of early- and late-onset fetal ventriculomegaly VM. Methods: A retrospective analysis was conducted on 102 pregnant women diagnosed with fetal VM, categorized into early-onset 24 weeks and late-onset 24 weeks groups. Maternal characteristics, ventricular dimensions, associated anomalies, pregnancy outcomes, and neonatal parameters were compared between the groups. Results: Early-onset VM was significantly associated with progressive ventricular enlargement, bilateral involvement, and a higher prevalence of additional anomalies detected via ultrasonography 70.4 vs. 29.2, P0.001 and Magnetic resonance imaging MRI 35.4 vs. 16.7, P0.030. Prenatal ultrasound findings differed significantly between the groups; early-onset VM cases more frequently exhibited bilateral 72.2 vs. 39.6, P0.002 and asymmetric 46.3 vs. 31.2, P0.037 ventricular enlargement, while late-onset VM was more commonly isolated 70.8 vs. 29.6, P0.001 and unilateral 60.4 vs. 27.8. Live birth rates were lower 55.6 vs. 85.4, P0.001, pregnancy termination rates were higher 44.4 vs. 14.6, P0.001 and chromosomal abnormalities were higher 16.7 vs. 8.3, P0.246 in early-onset cases. Additionally, Apgar scores at 1 and 5 minutes were significantly lower in the early-onset group P0.028 and P0.042, respectively. Conclusions: Early-onset VM is more frequently associated with ventricular progression and structural anomalies, leading to poorer pregnancy and neonatal outcomes. These findings highlight the importance of close prenatal monitoring, including detailed ultrasound, fetal MRI, and genetic evaluation, to guide clinical management and parental counseling. Future studies with long-term neurodevelopmental follow-up are needed to further refine risk stratification and optimize patient care.

 Objectives: This study aimed to compare the prenatal ultrasound characteristics, pregnancy outcomes, and neonatal prognosis of early- and late-onset fetal ventriculomegaly VM. Methods: A retrospective analysis was conducted on 102 pregnant women diagnosed with fetal VM, categorized into early-onset 24 weeks and late-onset 24 weeks groups. Maternal characteristics, ventricular dimensions, associated anomalies, pregnancy outcomes, and neonatal parameters were compared between the groups. Results: Early-onset VM was significantly associated with progressive ventricular enlargement, bilateral involvement, and a higher prevalence of additional anomalies detected via ultrasonography 70.4 vs. 29.2, P0.001 and Magnetic resonance imaging MRI 35.4 vs. 16.7, P0.030. Prenatal ultrasound findings differed significantly between the groups; early-onset VM cases more frequently exhibited bilateral 72.2 vs. 39.6, P0.002 and asymmetric 46.3 vs. 31.2, P0.037 ventricular enlargement, while late-onset VM was more commonly isolated 70.8 vs. 29.6, P0.001 and unilateral 60.4 vs. 27.8. Live birth rates were lower 55.6 vs. 85.4, P0.001, pregnancy termination rates were higher 44.4 vs. 14.6, P0.001 and chromosomal abnormalities were higher 16.7 vs. 8.3, P0.246 in early-onset cases. Additionally, Apgar scores at 1 and 5 minutes were significantly lower in the early-onset group P0.028 and P0.042, respectively. Conclusions: Early-onset VM is more frequently associated with ventricular progression and structural anomalies, leading to poorer pregnancy and neonatal outcomes. These findings highlight the importance of close prenatal monitoring, including detailed ultrasound, fetal MRI, and genetic evaluation, to guide clinical management and parental counseling. Future studies with long-term neurodevelopmental follow-up are needed to further refine risk stratification and optimize patient care.

 Objectives: This study aimed to compare the prenatal ultrasound characteristics, pregnancy outcomes, and neonatal prognosis of early- and late-onset fetal ventriculomegaly VM. Methods: A retrospective analysis was conducted on 102 pregnant women diagnosed with fetal VM, categorized into early-onset 24 weeks and late-onset 24 weeks groups. Maternal characteristics, ventricular dimensions, associated anomalies, pregnancy outcomes, and neonatal parameters were compared between the groups. Results: Early-onset VM was significantly associated with progressive ventricular enlargement, bilateral involvement, and a higher prevalence of additional anomalies detected via ultrasonography 70.4 vs. 29.2, P0.001 and Magnetic resonance imaging MRI 35.4 vs. 16.7, P0.030. Prenatal ultrasound findings differed significantly between the groups; early-onset VM cases more frequently exhibited bilateral 72.2 vs. 39.6, P0.002 and asymmetric 46.3 vs. 31.2, P0.037 ventricular enlargement, while late-onset VM was more commonly isolated 70.8 vs. 29.6, P0.001 and unilateral 60.4 vs. 27.8. Live birth rates were lower 55.6 vs. 85.4, P0.001, pregnancy termination rates were higher 44.4 vs. 14.6, P0.001 and chromosomal abnormalities were higher 16.7 vs. 8.3, P0.246 in early-onset cases. Additionally, Apgar scores at 1 and 5 minutes were significantly lower in the early-onset group P0.028 and P0.042, respectively. Conclusions: Early-onset VM is more frequently associated with ventricular progression and structural anomalies, leading to poorer pregnancy and neonatal outcomes. These findings highlight the importance of close prenatal monitoring, including detailed ultrasound, fetal MRI, and genetic evaluation, to guide clinical management and parental counseling. Future studies with long-term neurodevelopmental follow-up are needed to further refine risk stratification and optimize patient care.

Makale detayları

Early-onset versus late-onset fetal cerebral ventriculomegaly: Sonographic characteristics and neonatal outcomes

Yazarlar:

Ruken Dayanan | Ahmet Arif Filiz | Merve Ayas Özkan | Dilara Duygulu Bulan | Hatice Ayhan | Ecem Bakan | Gülşan Karabay | Şevki Çelen

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

The European Research Journal Vol.11 Issue 5, pp.885-895

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356987

pISSN:

2149-3189

Fetal cerebral ventriculomegaly

prenatal ultrasound

fetal MRI

pregnancy outcome

congenital anomalies

isolated ventriculomegaly

Sayı

Makale detayları

Early-onset versus late-onset fetal cerebral ventriculomegaly: Sonographic characteristics and neonatal outcomes

Yazarlar: Ruken Dayanan | Ahmet Arif Filiz | Merve Ayas Özkan | Dilara Duygulu Bulan | Hatice Ayhan | Ecem Bakan | Gülşan Karabay | Şevki Çelen

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Obstetrics and Gynaecology

Dergi: The European Research Journal Vol.11 Issue 5, pp.885-895

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001356987

pISSN: 2149-3189

Fetal cerebral ventriculomegaly

prenatal ultrasound

fetal MRI

pregnancy outcome

congenital anomalies

isolated ventriculomegaly

Sayı

Yazarlar:

Ruken Dayanan | Ahmet Arif Filiz | Merve Ayas Özkan | Dilara Duygulu Bulan | Hatice Ayhan | Ecem Bakan | Gülşan Karabay | Şevki Çelen

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Obstetrics and Gynaecology

Dergi:

The European Research Journal Vol.11 Issue 5, pp.885-895

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001356987

pISSN:

2149-3189