Investigation of the effects of apilarnil and imatinib use on liver and kidney tissues in rats via PI3K/AKT/mTOR and JAK2/STAT3 pathways

Cüneyt Çağlayan; Aydın Genç; Sefa Küçükler; Hakan İnci

Makale detayları

Investigation of the effects of apilarnil and imatinib use on liver and kidney tissues in rats via PI3K/AKT/mTOR and JAK2/STAT3 pathways

Yazarlar:

Cüneyt Çağlayan | Aydın Genç | Sefa Küçükler | Hakan İnci

Yayıncı:

Bingol University

Ana Başlıklar:

Sinyal İletimi

Dergi:

Türk Doğa ve Fen Dergisi Vol.13 Issue 3, pp.134-139

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328019

pISSN:

2149-6366

Anahtar kelimeler:

Özet:

 Imatinib, used in the field of molecular targeted therapy, has been reported to cause serious side effects, including liver and kidney failure. However, the mechanism of imatinib-induced liver and kidney toxicity remains unclear due to limited number of studies in this field. Apilarnil is a natural bee product produced from 3-7 day old drone larvae. The present study aimed to investigate the effects of apilarnil in rats with imatinib-induced liver and kidney toxicity using biochemical parameters. In the experiment, 35 wistar albino rats were divided into five groups n7: i Control, ii Apilarnil, iii İmatinib, iv İmatinibApilarnil-200, and v İmatinibApilarnil-400. The rats were treated orally with İmatinib 100 mgkg alone or with apilarnil 200 and 400 mgkg for 14 consecutive days. Imatinib reduced PI3K, AKT and mTOR levels, while increasing JAK2 and STAT3 levels in liver and kidney tissues. Apilarnil given for treatment modulated these values and provided partial protection in liver and kidney tissue. In conclusion, it was determined that apilarnil has ameliorative effects against imatinib-induced liver and kidney damage.

 Imatinib, used in the field of molecular targeted therapy, has been reported to cause serious side effects, including liver and kidney failure. However, the mechanism of imatinib-induced liver and kidney toxicity remains unclear due to limited number of studies in this field. Apilarnil is a natural bee product produced from 3-7 day old drone larvae. The present study aimed to investigate the effects of apilarnil in rats with imatinib-induced liver and kidney toxicity using biochemical parameters. In the experiment, 35 wistar albino rats were divided into five groups n7: i Control, ii Apilarnil, iii İmatinib, iv İmatinibApilarnil-200, and v İmatinibApilarnil-400. The rats were treated orally with İmatinib 100 mgkg alone or with apilarnil 200 and 400 mgkg for 14 consecutive days. Imatinib reduced PI3K, AKT and mTOR levels, while increasing JAK2 and STAT3 levels in liver and kidney tissues. Apilarnil given for treatment modulated these values and provided partial protection in liver and kidney tissue. In conclusion, it was determined that apilarnil has ameliorative effects against imatinib-induced liver and kidney damage.

 Imatinib, used in the field of molecular targeted therapy, has been reported to cause serious side effects, including liver and kidney failure. However, the mechanism of imatinib-induced liver and kidney toxicity remains unclear due to limited number of studies in this field. Apilarnil is a natural bee product produced from 3-7 day old drone larvae. The present study aimed to investigate the effects of apilarnil in rats with imatinib-induced liver and kidney toxicity using biochemical parameters. In the experiment, 35 wistar albino rats were divided into five groups n7: i Control, ii Apilarnil, iii İmatinib, iv İmatinibApilarnil-200, and v İmatinibApilarnil-400. The rats were treated orally with İmatinib 100 mgkg alone or with apilarnil 200 and 400 mgkg for 14 consecutive days. Imatinib reduced PI3K, AKT and mTOR levels, while increasing JAK2 and STAT3 levels in liver and kidney tissues. Apilarnil given for treatment modulated these values and provided partial protection in liver and kidney tissue. In conclusion, it was determined that apilarnil has ameliorative effects against imatinib-induced liver and kidney damage.

 Imatinib, used in the field of molecular targeted therapy, has been reported to cause serious side effects, including liver and kidney failure. However, the mechanism of imatinib-induced liver and kidney toxicity remains unclear due to limited number of studies in this field. Apilarnil is a natural bee product produced from 3-7 day old drone larvae. The present study aimed to investigate the effects of apilarnil in rats with imatinib-induced liver and kidney toxicity using biochemical parameters. In the experiment, 35 wistar albino rats were divided into five groups n7: i Control, ii Apilarnil, iii İmatinib, iv İmatinibApilarnil-200, and v İmatinibApilarnil-400. The rats were treated orally with İmatinib 100 mgkg alone or with apilarnil 200 and 400 mgkg for 14 consecutive days. Imatinib reduced PI3K, AKT and mTOR levels, while increasing JAK2 and STAT3 levels in liver and kidney tissues. Apilarnil given for treatment modulated these values and provided partial protection in liver and kidney tissue. In conclusion, it was determined that apilarnil has ameliorative effects against imatinib-induced liver and kidney damage.

Makale detayları

Investigation of the effects of apilarnil and imatinib use on liver and kidney tissues in rats via PI3K/AKT/mTOR and JAK2/STAT3 pathways

Yazarlar:

Cüneyt Çağlayan | Aydın Genç | Sefa Küçükler | Hakan İnci

Yayıncı:

Bingol University

Ana Başlıklar:

Sinyal İletimi

Dergi:

Türk Doğa ve Fen Dergisi Vol.13 Issue 3, pp.134-139

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328019

pISSN:

2149-6366

Apilarnil

İmatinib

Liver

Kidney

Rat

Sayı

Makale detayları

Investigation of the effects of apilarnil and imatinib use on liver and kidney tissues in rats via PI3K/AKT/mTOR and JAK2/STAT3 pathways

Yazarlar: Cüneyt Çağlayan | Aydın Genç | Sefa Küçükler | Hakan İnci

Yayıncı: Bingol University

Ana Başlıklar: Sinyal İletimi

Dergi: Türk Doğa ve Fen Dergisi Vol.13 Issue 3, pp.134-139

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001328019

pISSN: 2149-6366

Apilarnil

İmatinib

Liver

Kidney

Rat

Sayı

Yazarlar:

Cüneyt Çağlayan | Aydın Genç | Sefa Küçükler | Hakan İnci

Yayıncı:

Bingol University

Ana Başlıklar:

Sinyal İletimi

Dergi:

Türk Doğa ve Fen Dergisi Vol.13 Issue 3, pp.134-139

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328019

pISSN:

2149-6366