The Optimum Condition Design of Microwave-Assisted Extraction Combined Lactic Acid-Sucrose Based Natural Deep Eutectic Solvent on Polyphenols Enrichment from Eleutherine bulbosa Mill. Urb. Bulbs

N.A.

Makale detayları

The Optimum Condition Design of Microwave-Assisted Extraction Combined Lactic Acid-Sucrose Based Natural Deep Eutectic Solvent on Polyphenols Enrichment from Eleutherine bulbosa Mill. Urb. Bulbs

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 3, pp.1085-1095

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347903

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The advantages of natural deep eutectic solvent NADES for bioactive extraction to create formulations for nutraceuticals and cosmetics include biodegradability, biocompatibility, secondary metabolite extractability, and food grade. This study aims to design the optimum condition of microwave-assisted extraction MAE combined lactic acid-sucrose LA-Suc-based NADES on polyphenolic enrichment from the bulbs of Eleutherine bulbosa Mill. Urb. using response surface methodology. In the present study, the condition of MAE-combined LA-Suc-based NADES parameters, including NADES LA-Suc ratio, microwave irradiation time, solid-liquid ratio, and microwave irradiation power, had been involved. RSM with four factors and three levels Box-Behnken Design was applied to design a predictive model and optimize the MAE-combined LA-Suc-based NADES condition. The response surface was calculated using the total polyphenols content TPC value as the dependent variable. According to the result, the optimum condition of MAE combined LA-Suc based NADES was recommended according to RSM analysis as follows: NADES LA-Suc ratio of 4:1 gg, irradiation time of 10 min, the solid-liquid ratio of 1:10 gmL, and irradiation power of 360 Watts. The scale-up confirmation test using a 50 g sample ten times the number of the sample was observed to be 82.436.23 mg GAEg sample.

 The advantages of natural deep eutectic solvent NADES for bioactive extraction to create formulations for nutraceuticals and cosmetics include biodegradability, biocompatibility, secondary metabolite extractability, and food grade. This study aims to design the optimum condition of microwave-assisted extraction MAE combined lactic acid-sucrose LA-Suc-based NADES on polyphenolic enrichment from the bulbs of Eleutherine bulbosa Mill. Urb. using response surface methodology. In the present study, the condition of MAE-combined LA-Suc-based NADES parameters, including NADES LA-Suc ratio, microwave irradiation time, solid-liquid ratio, and microwave irradiation power, had been involved. RSM with four factors and three levels Box-Behnken Design was applied to design a predictive model and optimize the MAE-combined LA-Suc-based NADES condition. The response surface was calculated using the total polyphenols content TPC value as the dependent variable. According to the result, the optimum condition of MAE combined LA-Suc based NADES was recommended according to RSM analysis as follows: NADES LA-Suc ratio of 4:1 gg, irradiation time of 10 min, the solid-liquid ratio of 1:10 gmL, and irradiation power of 360 Watts. The scale-up confirmation test using a 50 g sample ten times the number of the sample was observed to be 82.436.23 mg GAEg sample.

 The advantages of natural deep eutectic solvent NADES for bioactive extraction to create formulations for nutraceuticals and cosmetics include biodegradability, biocompatibility, secondary metabolite extractability, and food grade. This study aims to design the optimum condition of microwave-assisted extraction MAE combined lactic acid-sucrose LA-Suc-based NADES on polyphenolic enrichment from the bulbs of Eleutherine bulbosa Mill. Urb. using response surface methodology. In the present study, the condition of MAE-combined LA-Suc-based NADES parameters, including NADES LA-Suc ratio, microwave irradiation time, solid-liquid ratio, and microwave irradiation power, had been involved. RSM with four factors and three levels Box-Behnken Design was applied to design a predictive model and optimize the MAE-combined LA-Suc-based NADES condition. The response surface was calculated using the total polyphenols content TPC value as the dependent variable. According to the result, the optimum condition of MAE combined LA-Suc based NADES was recommended according to RSM analysis as follows: NADES LA-Suc ratio of 4:1 gg, irradiation time of 10 min, the solid-liquid ratio of 1:10 gmL, and irradiation power of 360 Watts. The scale-up confirmation test using a 50 g sample ten times the number of the sample was observed to be 82.436.23 mg GAEg sample.

 The advantages of natural deep eutectic solvent NADES for bioactive extraction to create formulations for nutraceuticals and cosmetics include biodegradability, biocompatibility, secondary metabolite extractability, and food grade. This study aims to design the optimum condition of microwave-assisted extraction MAE combined lactic acid-sucrose LA-Suc-based NADES on polyphenolic enrichment from the bulbs of Eleutherine bulbosa Mill. Urb. using response surface methodology. In the present study, the condition of MAE-combined LA-Suc-based NADES parameters, including NADES LA-Suc ratio, microwave irradiation time, solid-liquid ratio, and microwave irradiation power, had been involved. RSM with four factors and three levels Box-Behnken Design was applied to design a predictive model and optimize the MAE-combined LA-Suc-based NADES condition. The response surface was calculated using the total polyphenols content TPC value as the dependent variable. According to the result, the optimum condition of MAE combined LA-Suc based NADES was recommended according to RSM analysis as follows: NADES LA-Suc ratio of 4:1 gg, irradiation time of 10 min, the solid-liquid ratio of 1:10 gmL, and irradiation power of 360 Watts. The scale-up confirmation test using a 50 g sample ten times the number of the sample was observed to be 82.436.23 mg GAEg sample.

Makale detayları

The Optimum Condition Design of Microwave-Assisted Extraction Combined Lactic Acid-Sucrose Based Natural Deep Eutectic Solvent on Polyphenols Enrichment from Eleutherine bulbosa Mill. Urb. Bulbs

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 3, pp.1085-1095

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347903

pISSN:

2630-6344

Eleutherin bulbosa Mill. Urb.

Box-Behnken Design

natural deep eutectic solvent

response surface methodology

Sayı

Makale detayları

The Optimum Condition Design of Microwave-Assisted Extraction Combined Lactic Acid-Sucrose Based Natural Deep Eutectic Solvent on Polyphenols Enrichment from Eleutherine bulbosa Mill. Urb. Bulbs

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.27 Issue 3, pp.1085-1095

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347903

pISSN: 2630-6344

Eleutherin bulbosa Mill. Urb.

Box-Behnken Design

natural deep eutectic solvent

response surface methodology

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 3, pp.1085-1095

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347903

pISSN:

2630-6344