Investigating the Ku70 (XRCC6) gene polymorphism in patients with gastric cancer

Sezin Canbek

Makale detayları

Investigating the Ku70 (XRCC6) gene polymorphism in patients with gastric cancer

Yazarlar:

Sezin Canbek

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Clinical Oncology

Dergi:

Developments and Experiments in Health and Medicine Vol.39 Issue 2, pp.111-126

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348275

pISSN:

3062-2948

Anahtar kelimeler:

Özet:

 BACKGROUND The DNA repair gene Ku70, a key component of the non-homologous end-joining repair pathway, plays a crucial role in the repair of DNA double strand breaks DSBs. Deficiencies in DSB repair may result in permanent genomic instability. However, the association between polymorphic variations of Ku70 and susceptibility to gastric cancer remains unclear. OBJECTIVE This study aims to investigate the potential correlation between the Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms and the risk of developing gastric cancer in the Turkish population. METHOD A hospital-based case-control study was conducted, including 92 patients diagnosed with gastric cancer and 194 age- and gender-matched healthy controls. Genotyping of Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms was performed using real-time PCR at Dokuz Eylül University Hospital, Izmir. RESULTS No significant difference was observed in the distribution of genotype frequencies for either polymorphism between the gastric cancer patients and the control group. The Chi-Square test revealed no significant difference in the frequencies of the G-57C rs2267437 polymorphism between the cancer group and the control group. The CC genotype was absent in the cancer group, while it was present in one in the control group. The GG genotype of intron 3 rs132774 polymorphism was also absent in both groups. The Chi-Square test revealed no significant difference between the two groups. CONCLUSION The presence of the Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms does not appear to increase the risk of gastric cancer in the Turkish population.

 BACKGROUND The DNA repair gene Ku70, a key component of the non-homologous end-joining repair pathway, plays a crucial role in the repair of DNA double strand breaks DSBs. Deficiencies in DSB repair may result in permanent genomic instability. However, the association between polymorphic variations of Ku70 and susceptibility to gastric cancer remains unclear. OBJECTIVE This study aims to investigate the potential correlation between the Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms and the risk of developing gastric cancer in the Turkish population. METHOD A hospital-based case-control study was conducted, including 92 patients diagnosed with gastric cancer and 194 age- and gender-matched healthy controls. Genotyping of Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms was performed using real-time PCR at Dokuz Eylül University Hospital, Izmir. RESULTS No significant difference was observed in the distribution of genotype frequencies for either polymorphism between the gastric cancer patients and the control group. The Chi-Square test revealed no significant difference in the frequencies of the G-57C rs2267437 polymorphism between the cancer group and the control group. The CC genotype was absent in the cancer group, while it was present in one in the control group. The GG genotype of intron 3 rs132774 polymorphism was also absent in both groups. The Chi-Square test revealed no significant difference between the two groups. CONCLUSION The presence of the Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms does not appear to increase the risk of gastric cancer in the Turkish population.

 BACKGROUND The DNA repair gene Ku70, a key component of the non-homologous end-joining repair pathway, plays a crucial role in the repair of DNA double strand breaks DSBs. Deficiencies in DSB repair may result in permanent genomic instability. However, the association between polymorphic variations of Ku70 and susceptibility to gastric cancer remains unclear. OBJECTIVE This study aims to investigate the potential correlation between the Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms and the risk of developing gastric cancer in the Turkish population. METHOD A hospital-based case-control study was conducted, including 92 patients diagnosed with gastric cancer and 194 age- and gender-matched healthy controls. Genotyping of Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms was performed using real-time PCR at Dokuz Eylül University Hospital, Izmir. RESULTS No significant difference was observed in the distribution of genotype frequencies for either polymorphism between the gastric cancer patients and the control group. The Chi-Square test revealed no significant difference in the frequencies of the G-57C rs2267437 polymorphism between the cancer group and the control group. The CC genotype was absent in the cancer group, while it was present in one in the control group. The GG genotype of intron 3 rs132774 polymorphism was also absent in both groups. The Chi-Square test revealed no significant difference between the two groups. CONCLUSION The presence of the Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms does not appear to increase the risk of gastric cancer in the Turkish population.

 BACKGROUND The DNA repair gene Ku70, a key component of the non-homologous end-joining repair pathway, plays a crucial role in the repair of DNA double strand breaks DSBs. Deficiencies in DSB repair may result in permanent genomic instability. However, the association between polymorphic variations of Ku70 and susceptibility to gastric cancer remains unclear. OBJECTIVE This study aims to investigate the potential correlation between the Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms and the risk of developing gastric cancer in the Turkish population. METHOD A hospital-based case-control study was conducted, including 92 patients diagnosed with gastric cancer and 194 age- and gender-matched healthy controls. Genotyping of Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms was performed using real-time PCR at Dokuz Eylül University Hospital, Izmir. RESULTS No significant difference was observed in the distribution of genotype frequencies for either polymorphism between the gastric cancer patients and the control group. The Chi-Square test revealed no significant difference in the frequencies of the G-57C rs2267437 polymorphism between the cancer group and the control group. The CC genotype was absent in the cancer group, while it was present in one in the control group. The GG genotype of intron 3 rs132774 polymorphism was also absent in both groups. The Chi-Square test revealed no significant difference between the two groups. CONCLUSION The presence of the Ku70 promoter G-57C rs2267437 and intron 3 rs132774 polymorphisms does not appear to increase the risk of gastric cancer in the Turkish population.

Makale detayları

Investigating the Ku70 (XRCC6) gene polymorphism in patients with gastric cancer

Yazarlar:

Sezin Canbek

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Clinical Oncology

Dergi:

Developments and Experiments in Health and Medicine Vol.39 Issue 2, pp.111-126

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348275

pISSN:

3062-2948

Case-control study

DNA repair

gastric cancer

Ku70 gene

polymorphisms

Sayı

Makale detayları

Investigating the Ku70 (XRCC6) gene polymorphism in patients with gastric cancer

Yazarlar: Sezin Canbek

Yayıncı: Dokuz Eylul University

Ana Başlıklar: Clinical Oncology

Dergi: Developments and Experiments in Health and Medicine Vol.39 Issue 2, pp.111-126

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348275

pISSN: 3062-2948

Case-control study

DNA repair

gastric cancer

Ku70 gene

polymorphisms

Sayı

Yazarlar:

Sezin Canbek

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Clinical Oncology

Dergi:

Developments and Experiments in Health and Medicine Vol.39 Issue 2, pp.111-126

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348275

pISSN:

3062-2948