Relationship between nonmotor symptoms and neutrophil-to-lymphocyte ratio in Parkinson’s disease

Dilek İşcan; Gürkan Demirtaş; Aslı Demirtaş

Makale detayları

Relationship between nonmotor symptoms and neutrophil-to-lymphocyte ratio in Parkinson’s disease

Yazarlar:

Dilek İşcan | Gürkan Demirtaş | Aslı Demirtaş

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.916-924

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329046

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: The aim of this study was to investigate the relationship between neutrophil-to-lymphocyte ratio NLR, an inflammation marker, and nonmotor symptoms, such as fatigue, sleep disturbances, and overall quality of life, in Parkinsons disease PD. Materials and Methods: This study included 60 patients diagnosed with PD 17 female and 43 male. Fatigue was assessed using the Parkinsons Disease Fatigue Scale PFS-16, sleep quality using the Parkinsons Disease Sleep Scale PDSS, and quality of life using the Parkinsons Disease Questionnaire-8 PDQ-8. Neutrophil and lymphocyte counts were extracted from the complete blood count results, and the NLR was calculated. Results: A moderate, negative correlation was observed between fatigue and sleep quality; a moderate, positive correlation was observed between quality of life, motor rating, and disease staging; a moderate, negative correlation was observed between sleep quality and quality of life; a weak, negative correlation was observed between sleep quality, motor rating, and disease staging; and a weak, positive correlation was found between quality of life, motor rating, and disease staging. No significant relationship was observed between NLR and nonmotor symptoms in PD. Conclusion: Further prospective studies with larger samples or casecontrol designs are warranted to explore the potential clinical utility of a simple, cost-effective biomarker, such as NLR, in assessing PD symptoms and disease progression.

 Purpose: The aim of this study was to investigate the relationship between neutrophil-to-lymphocyte ratio NLR, an inflammation marker, and nonmotor symptoms, such as fatigue, sleep disturbances, and overall quality of life, in Parkinsons disease PD. Materials and Methods: This study included 60 patients diagnosed with PD 17 female and 43 male. Fatigue was assessed using the Parkinsons Disease Fatigue Scale PFS-16, sleep quality using the Parkinsons Disease Sleep Scale PDSS, and quality of life using the Parkinsons Disease Questionnaire-8 PDQ-8. Neutrophil and lymphocyte counts were extracted from the complete blood count results, and the NLR was calculated. Results: A moderate, negative correlation was observed between fatigue and sleep quality; a moderate, positive correlation was observed between quality of life, motor rating, and disease staging; a moderate, negative correlation was observed between sleep quality and quality of life; a weak, negative correlation was observed between sleep quality, motor rating, and disease staging; and a weak, positive correlation was found between quality of life, motor rating, and disease staging. No significant relationship was observed between NLR and nonmotor symptoms in PD. Conclusion: Further prospective studies with larger samples or casecontrol designs are warranted to explore the potential clinical utility of a simple, cost-effective biomarker, such as NLR, in assessing PD symptoms and disease progression.

 Purpose: The aim of this study was to investigate the relationship between neutrophil-to-lymphocyte ratio NLR, an inflammation marker, and nonmotor symptoms, such as fatigue, sleep disturbances, and overall quality of life, in Parkinsons disease PD. Materials and Methods: This study included 60 patients diagnosed with PD 17 female and 43 male. Fatigue was assessed using the Parkinsons Disease Fatigue Scale PFS-16, sleep quality using the Parkinsons Disease Sleep Scale PDSS, and quality of life using the Parkinsons Disease Questionnaire-8 PDQ-8. Neutrophil and lymphocyte counts were extracted from the complete blood count results, and the NLR was calculated. Results: A moderate, negative correlation was observed between fatigue and sleep quality; a moderate, positive correlation was observed between quality of life, motor rating, and disease staging; a moderate, negative correlation was observed between sleep quality and quality of life; a weak, negative correlation was observed between sleep quality, motor rating, and disease staging; and a weak, positive correlation was found between quality of life, motor rating, and disease staging. No significant relationship was observed between NLR and nonmotor symptoms in PD. Conclusion: Further prospective studies with larger samples or casecontrol designs are warranted to explore the potential clinical utility of a simple, cost-effective biomarker, such as NLR, in assessing PD symptoms and disease progression.

 Amaç: Bu çalışmanın amacı bir inflamasyon belirteci olan nötrofillenfosit oranı NLR ile Parkinson Hastalığında PH yorgunluk, uyku ve yaşam kalitesi arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Araştırma örneklemimiz PH tanısı konmuş toplam 60 hastadan 17 kadın, 43 erkek oluşmaktadır. Yorgunluk Parkinson Hastalığı Yorgunluk Ölçeği PFS-16, uyku kalitesi Parkinson Hastalığı Uyku Ölçeği PDSS ve yaşam kalitesi Parkinson Hastalığı Anketi-8 PDQ-8 ile değerlendirilmiştir. Nötrofil ve lenfosit sayıları hemogram testi ile elde edilmiş ve oranlanarak hesaplanmıştır. Bulgular: PH hastalarında yorgunluk ile uyku kalitesi arasında anlamlı, negatif ve orta düzeyde; yaşam kalitesi, motor derecelendirme ve hastalık evrelemesi arasında pozitif ve orta düzeyde; uyku kalitesi ile yaşam kalitesi arasında negatif ve orta düzeyde; uyku kalitesi ile motor derecelendirme ve hastalık evrelemesi arasında negatif ve zayıf düzeyde; yaşam kalitesi ile motor derecelendirme ve hastalık evrelemesi arasında pozitif ve zayıf düzeyde korelasyon bulunmuştur. Non-motor semptomlar ile NLR arasında ilişki bulunmamıştır. Sonuç: NLR gibi basit, ucuz bir biyobelirteçin PH takibi bağlamında potansiyel klinik avantajlarını ve bu tür biyobelirteçlerin hastalık semptomları üzerindeki etkisini belirlemek için çok daha büyük bir kohort veya vaka-kontrol içeren daha ileri prospektif çalışmalar yol gösterici olabilir.

Makale detayları

Relationship between nonmotor symptoms and neutrophil-to-lymphocyte ratio in Parkinson’s disease

Yazarlar:

Dilek İşcan | Gürkan Demirtaş | Aslı Demirtaş

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.916-924

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329046

pISSN:

2602-3032

Parkinson’s Disease

fatigue

sleep disorders

quality of life

neutrophil-to-lymphocyte ratio.Parkinson Hastalığı

yorgunluk

uyku bozuklukları

yaşam kalitesi

nötrofil/lenfosit oranı

Sayı

Makale detayları

Yazarlar: Dilek İşcan | Gürkan Demirtaş | Aslı Demirtaş

Yayıncı: Cukurova University

Ana Başlıklar: Nöroloji ve Nöromüsküler Hastalıklar

Dergi: Cukurova Medical Journal Vol.49 Issue 4, pp.916-924

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001329046

pISSN: 2602-3032

Sayı

Yazarlar:

Dilek İşcan | Gürkan Demirtaş | Aslı Demirtaş

Yayıncı:

Cukurova University

Ana Başlıklar:

Nöroloji ve Nöromüsküler Hastalıklar

Dergi:

Cukurova Medical Journal Vol.49 Issue 4, pp.916-924

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001329046

pISSN:

2602-3032