Clinical Markers Predicting Mortality in Patients Receiving Renal Replacement Therapy in the Intensive Care Unit: A One-Year Retrospective Study

Volkan Alparslan; Samet Kutlu; Özlem Güler; Metin Ergül; İpek İzgin Avcı; Nur Baykara; Alparslan Kuş

Makale detayları

Clinical Markers Predicting Mortality in Patients Receiving Renal Replacement Therapy in the Intensive Care Unit: A One-Year Retrospective Study

Yazarlar:

Volkan Alparslan | Samet Kutlu | Özlem Güler | Metin Ergül | İpek İzgin Avcı | Nur Baykara | Alparslan Kuş

Yayıncı:

Kocaeli University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi Vol.11 Issue 3, pp.171-176

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359764

pISSN:

2149-8571

Anahtar kelimeler:

Özet:

 Objective: Acute kidney injury AKI necessitating continuous renal replacement therapy CRRT is linked to elevated mortality rates in the intensive care unit ICU. Finding prognostic markers affects each persons care are still very important. The objective of this study was to determine clinical and biochemical predictors of intensive care unit mortality in patients undergoing CRRT. Methods: This retrospective single-center study encompassed 130 adult ICU patients who underwent CRRT from January 2024 to January 2025. For the mortality analysis, patients were divided into two groups: surviving and exitus. For the secondary analysis, they were divided into two groups: early CRRT and late CRRT, based on when they started. Results: The mortality rate in the ICU was 83.8 n109. In multivariable logistic regression, a higher SOFA score OR: 2.18; 95 GA: 1.383.45; p0.001, increased serum creatinine OR: 0.59; 95 GA: 0.360.94; p0.029, levels were independently linked to mortality. There was no significant difference in mortality between the early 57.7 and late 42.3 CRRT initiation groups p0.05. The late group, on the other hand, stayed in the ICU and the hospital for a lot longer and got more Prismocal solution p0.05. Conclusion: This study identified several clinical and biochemical parameters as independent predictors of mortality in CRRT-treated ICU patients. Although early CRRT initiation did not significantly impact survival, it was associated with reduced use of dialysis solution and shorter ICU and hospital stays. These findings suggest that integrating prognostic markers into clinical decision-making may improve outcome prediction.

 Objective: Acute kidney injury AKI necessitating continuous renal replacement therapy CRRT is linked to elevated mortality rates in the intensive care unit ICU. Finding prognostic markers affects each persons care are still very important. The objective of this study was to determine clinical and biochemical predictors of intensive care unit mortality in patients undergoing CRRT. Methods: This retrospective single-center study encompassed 130 adult ICU patients who underwent CRRT from January 2024 to January 2025. For the mortality analysis, patients were divided into two groups: surviving and exitus. For the secondary analysis, they were divided into two groups: early CRRT and late CRRT, based on when they started. Results: The mortality rate in the ICU was 83.8 n109. In multivariable logistic regression, a higher SOFA score OR: 2.18; 95 GA: 1.383.45; p0.001, increased serum creatinine OR: 0.59; 95 GA: 0.360.94; p0.029, levels were independently linked to mortality. There was no significant difference in mortality between the early 57.7 and late 42.3 CRRT initiation groups p0.05. The late group, on the other hand, stayed in the ICU and the hospital for a lot longer and got more Prismocal solution p0.05. Conclusion: This study identified several clinical and biochemical parameters as independent predictors of mortality in CRRT-treated ICU patients. Although early CRRT initiation did not significantly impact survival, it was associated with reduced use of dialysis solution and shorter ICU and hospital stays. These findings suggest that integrating prognostic markers into clinical decision-making may improve outcome prediction.

 Objective: Acute kidney injury AKI necessitating continuous renal replacement therapy CRRT is linked to elevated mortality rates in the intensive care unit ICU. Finding prognostic markers affects each persons care are still very important. The objective of this study was to determine clinical and biochemical predictors of intensive care unit mortality in patients undergoing CRRT. Methods: This retrospective single-center study encompassed 130 adult ICU patients who underwent CRRT from January 2024 to January 2025. For the mortality analysis, patients were divided into two groups: surviving and exitus. For the secondary analysis, they were divided into two groups: early CRRT and late CRRT, based on when they started. Results: The mortality rate in the ICU was 83.8 n109. In multivariable logistic regression, a higher SOFA score OR: 2.18; 95 GA: 1.383.45; p0.001, increased serum creatinine OR: 0.59; 95 GA: 0.360.94; p0.029, levels were independently linked to mortality. There was no significant difference in mortality between the early 57.7 and late 42.3 CRRT initiation groups p0.05. The late group, on the other hand, stayed in the ICU and the hospital for a lot longer and got more Prismocal solution p0.05. Conclusion: This study identified several clinical and biochemical parameters as independent predictors of mortality in CRRT-treated ICU patients. Although early CRRT initiation did not significantly impact survival, it was associated with reduced use of dialysis solution and shorter ICU and hospital stays. These findings suggest that integrating prognostic markers into clinical decision-making may improve outcome prediction.

 Amaç: Akut böbrek hasarı ABH, yoğun bakımda yüksek mortalite ile ilişkilidir. Yoğun bakımda akut böbrek hasarının tedavisinde sürekli renal replasman tedavisi SRRT uygulanır. Mortalite için prognostik belirteçlerin saptanması ve SRRTnin erken veya geç başlanmasının hasta bakımına etkisinin belirlenmesi kritik öneme sahiptir. Çalışmamızın amacı SRRT alan YBÜ hastalarında mortaliteyi öngören klinik ve biyokimyasal belirleyicileri incelemek ve erken ile geç SRRT başlama gruplarının sonuçlarını karşılaştırmaktır. Yöntem: Bu retrospektif, tek merkezli çalışmaya Ocak 2024Ocak 2025 tarihleri arasında YBÜde SRRT uygulanan 130 erişkin hasta dahil edildi. Demografik veriler, hastalık şiddet skorları SOFA ve APACHE II, laboratuvar değerleri ve SRRT başlama zamanı incelendi. Mortalite analizinde hastalar yaşayanlar ve ölenler olarak iki gruba ayrıldı. İkincil analizde ise başlama zamanına göre erken ve geç başlanan SRRT grupları karşılaştırıldı. Bulgular: Mortalite oranı 83,8 N109 idi. Çok değişkenli lojistik regresyon analizinde yüksek SOFA skoru OR: 2,18; 95 GA: 1,383,45; p0,001, artmış serum kreatinin düzeyi OR: 0,59; 95 GA: 0,360,94; p0,029, düşük trombosit sayısı, hipoalbüminemi, yüksek INR ve CRP düzeyleri mortalite ile bağımsız olarak ilişkili bulundu. Erken 57,7 ve geç 42,3 SRRT başlama grupları arasında mortalite açısından anlamlı fark yoktu p0,05. Geç gruptaki hastalar, erken gruba kıyasla daha uzun süre YBÜ ve hastanede yatış gerektirdi ve daha fazla Prismocal solüsyonu aldı p0,05. Sonuç: Bu çalışma, SOFA skoru ve serum kreatinin düzeyi de dahil olmak üzere çeşitli klinik ve biyokimyasal parametrelerin, SRRT uygulanan YBÜ hastalarında mortalitenin bağımsız öngördürücüleri olduğunu göstermiştir. Erken SRRT başlatılması sağkalımı etkilememekle birlikte, daha az diyaliz solüsyonu kullanımı ve daha kısa YBÜ ile hastane yatış süresi ile ilişkilidir. Bulgular, prognostik belirteçlerin klinik karar verme sürecine dahil edilmesinin sonuç tahminlerinin doğruluğunu artırabileceğini, ayrıca SRRTnin erken başlatılmasının mortaliteyi değiştirmese bile lojistik ve kaynak kullanımı açısından avantaj sağlayabileceğini göstermektedir. .

Makale detayları

Clinical Markers Predicting Mortality in Patients Receiving Renal Replacement Therapy in the Intensive Care Unit: A One-Year Retrospective Study

Yazarlar:

Volkan Alparslan | Samet Kutlu | Özlem Güler | Metin Ergül | İpek İzgin Avcı | Nur Baykara | Alparslan Kuş

Yayıncı:

Kocaeli University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi Vol.11 Issue 3, pp.171-176

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359764

pISSN:

2149-8571

Renal replacement therapy

acute kidney injury

intensive care unit

sepsis-associated AKI

critical care outcomes

mortalityRenal replasman tedavisi,

Akut böbrek hasarı,

Yoğun bakım

Sayı

Makale detayları

Yazarlar: Volkan Alparslan | Samet Kutlu | Özlem Güler | Metin Ergül | İpek İzgin Avcı | Nur Baykara | Alparslan Kuş

Yayıncı: Kocaeli University

Ana Başlıklar: Yoğun Bakım

Dergi: Kocaeli Üniversitesi Sağlık Bilimleri Dergisi Vol.11 Issue 3, pp.171-176

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001359764

pISSN: 2149-8571

Sayı

Yazarlar:

Volkan Alparslan | Samet Kutlu | Özlem Güler | Metin Ergül | İpek İzgin Avcı | Nur Baykara | Alparslan Kuş

Yayıncı:

Kocaeli University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi Vol.11 Issue 3, pp.171-176

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359764

pISSN:

2149-8571