BLACK CARROT JUICE: A NEW APPROACH to CURE ACRYLAMIDE-INDUCED HEPATOTOXICITY in RATS

Alper YALÇIN; Hıdır PEKMEZ

Makale detayları

BLACK CARROT JUICE: A NEW APPROACH to CURE ACRYLAMIDE-INDUCED HEPATOTOXICITY in RATS

Yazarlar:

Alper YALÇIN | Hıdır PEKMEZ

Yayıncı:

Ankara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Ankara Health Sciences 2020 Vol.9 Issue 1, pp.207-216

Belge Tipi:

Makale

Yayın Tarihi:

6/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000867697

Sıklık:

İki Yıllık

eISSN:

2618-5989

pISSN:

2146-328X

Anahtar kelimeler:

Özet:

 

Objective: The liver is exposed to many harmful agents, which cause hepatotoxicity due to oxidative stress. Acrylamide is a carcinogenic agent and has toxic effects on the liver. In this study we aimed to examine whether black carrot juice might protect rat liver from toxicities of acrylamide. Method: Thirty-two male Wistar albino rats were divided into four equal groups as follows: control, acrylamide, black carrot juice and acrylamide + black carrot juice All the treatments were administered every other day for 30 days. Liver tissues were analysed for routine histopathology and apoptosis whereas serum samples were evaluated for oxidation state. Results: In the acrylamide group, severe histopathological damage, including hepatocyte degeneration, sinusoidal dilatation, and passive hyperemia, along with a significant increase in caspase-3 immunoreactivity was observed. Biochemically the serum total antioxidant status  decreased significantly, and the serum total oxidant status increased significantly. The histopathological examination revealed significant amelioration of tissue damage in the acrylamide + black carrot juice group as compared with that in the acrylamide group. Moreover, total oxidant status decreased significantly, whereas the total antioxidant status increased significantly. Caspase-3 immunoreactivity also decreased insignificantly. Conclusion: Black carrot juice appears to exhibit therapeutic effects against acrylamide-induced hepatotoxicity due to its antioxidant properties.

Makale detayları

BLACK CARROT JUICE: A NEW APPROACH to CURE ACRYLAMIDE-INDUCED HEPATOTOXICITY in RATS

Yazarlar: Alper YALÇIN | Hıdır PEKMEZ

Yayıncı: Ankara University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Ankara Health Sciences 2020 Vol.9 Issue 1, pp.207-216

Belge Tipi: Makale

Yayın Tarihi: 6/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000867697

Sıklık: İki Yıllık

eISSN: 2618-5989

pISSN: 2146-328X

Acrylamide

black carrot juice

caspase-3

hepatotoxicity

total antioxidant status

total oxidant status

Sayı

Yazarlar:

Alper YALÇIN | Hıdır PEKMEZ

Yayıncı:

Ankara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Ankara Health Sciences 2020 Vol.9 Issue 1, pp.207-216

Belge Tipi:

Makale

Yayın Tarihi:

6/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000867697

Sıklık:

İki Yıllık

eISSN:

2618-5989

pISSN:

2146-328X