Effect of Melatonin on Hepatic Fibrogenesis, Vitamin C and Hydroxyproline Levels in Liver of Ethanol-Fed Rats

Bilal ÜSTÜNDAĞ

Makale detayları

Effect of Melatonin on Hepatic Fibrogenesis, Vitamin C and Hydroxyproline Levels in Liver of Ethanol-Fed Rats

Yazarlar:

Bilal ÜSTÜNDAĞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.333-340

Belge Tipi:

Makale

Yayın Tarihi:

3/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757573

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Pineal-gland-derived melatonin (N-  Acetyl 5-Methoxytryptamine), which is a  known antioxidant hormone, is known to  have inhibitory effects on cell growth and  proliferation. Ethanol causes increases in lipid  peroxidation, superoxide formation and  collagen synthesis resulting in fibrosis in the  liver due to alcohol intake. The aim of this  study was to examine the effect of  exogenously administered melatonin on liver  tissue damage resulting from alcohol intake.  A total of 30 male wistar albino rats were  divided into three groups; Group 1 (control),  Group 2 (ethanol-administration), and Group  3 (ethanol +melatonin administration). All  the rats were fed with a specially modified  diet for one week. At the end of the 1 st  week, the control group rats were given  isocaloric sucrose, while Group 2 and Group  3 rats were given gradually increasing  amounts of ethanol to induce liver damage.  The third group also received melatonin (10  mg/kg/day) together with ethanol.  Biochemical and histopathological findings  revealed the formation of liver damage after  the ethanol application was completed. There  was a significant increase (p.

 

Pineal-gland-derived melatonin (N-  Acetyl 5-Methoxytryptamine), which is a  known antioxidant hormone, is known to  have inhibitory effects on cell growth and  proliferation. Ethanol causes increases in lipid  peroxidation, superoxide formation and  collagen synthesis resulting in fibrosis in the  liver due to alcohol intake. The aim of this  study was to examine the effect of  exogenously administered melatonin on liver  tissue damage resulting from alcohol intake.  A total of 30 male wistar albino rats were  divided into three groups; Group 1 (control),  Group 2 (ethanol-administration), and Group  3 (ethanol +melatonin administration). All  the rats were fed with a specially modified  diet for one week. At the end of the 1 st  week, the control group rats were given  isocaloric sucrose, while Group 2 and Group  3 rats were given gradually increasing  amounts of ethanol to induce liver damage.  The third group also received melatonin (10  mg/kg/day) together with ethanol.  Biochemical and histopathological findings  revealed the formation of liver damage after  the ethanol application was completed. There  was a significant increase (p.

Makale detayları

Effect of Melatonin on Hepatic Fibrogenesis, Vitamin C and Hydroxyproline Levels in Liver of Ethanol-Fed Rats

Yazarlar:

Bilal ÜSTÜNDAĞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.333-340

Belge Tipi:

Makale

Yayın Tarihi:

3/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757573

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Hydroxyproline

ascorbic acid

alcoholic fibrosis

melatonin.

Sayı

Makale detayları

Effect of Melatonin on Hepatic Fibrogenesis, Vitamin C and Hydroxyproline Levels in Liver of Ethanol-Fed Rats

Yazarlar: Bilal ÜSTÜNDAĞ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.333-340

Belge Tipi: Makale

Yayın Tarihi: 3/2000

Belge Dili: Türkçe

Document ID (Org No.): 2000757573

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Hydroxyproline

ascorbic acid

alcoholic fibrosis

melatonin.

Sayı

Yazarlar:

Bilal ÜSTÜNDAĞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 4, pp.333-340

Belge Tipi:

Makale

Yayın Tarihi:

3/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757573

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144