Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Sevil Şenkardeş; Merve Eylül Kıymacı; Ş.güniz Küçükgüzel

Makale detayları

Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Yazarlar:

Sevil Şenkardeş | Merve Eylül Kıymacı | Ş.güniz Küçükgüzel

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.135-141

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347806

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 In this study, some N substituted arylmethylidene-4nitrobenzenesulfonohydrazide derivatives were synthesis by reacting various aldehydes and 4nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed by IR, 1H-NMR and TOF-MS compounds 3b and 3e spectroscopic data besides elementel analyses results. The antibacterial activities of these compounds were examined against some bacteria species. The compounds showed the highest activity against Pseudomonas aeruginosa ATCC 27853. Also, anti-quorum sensing activities have been determined using a biosensor bioassay with Chromobacterium violaceum CV026 and the signaling molecule N- hexanoyl-L-homoserine lactone. All the compounds were subjected for ADME predictions by computational method.

 In this study, some N substituted arylmethylidene-4nitrobenzenesulfonohydrazide derivatives were synthesis by reacting various aldehydes and 4nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed by IR, 1H-NMR and TOF-MS compounds 3b and 3e spectroscopic data besides elementel analyses results. The antibacterial activities of these compounds were examined against some bacteria species. The compounds showed the highest activity against Pseudomonas aeruginosa ATCC 27853. Also, anti-quorum sensing activities have been determined using a biosensor bioassay with Chromobacterium violaceum CV026 and the signaling molecule N- hexanoyl-L-homoserine lactone. All the compounds were subjected for ADME predictions by computational method.

 In this study, some N substituted arylmethylidene-4nitrobenzenesulfonohydrazide derivatives were synthesis by reacting various aldehydes and 4nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed by IR, 1H-NMR and TOF-MS compounds 3b and 3e spectroscopic data besides elementel analyses results. The antibacterial activities of these compounds were examined against some bacteria species. The compounds showed the highest activity against Pseudomonas aeruginosa ATCC 27853. Also, anti-quorum sensing activities have been determined using a biosensor bioassay with Chromobacterium violaceum CV026 and the signaling molecule N- hexanoyl-L-homoserine lactone. All the compounds were subjected for ADME predictions by computational method.

 In this study, some N substituted arylmethylidene-4nitrobenzenesulfonohydrazide derivatives were synthesis by reacting various aldehydes and 4nitrobenzenesulfonohydrazide. The structural characterization of the compounds was performed by IR, 1H-NMR and TOF-MS compounds 3b and 3e spectroscopic data besides elementel analyses results. The antibacterial activities of these compounds were examined against some bacteria species. The compounds showed the highest activity against Pseudomonas aeruginosa ATCC 27853. Also, anti-quorum sensing activities have been determined using a biosensor bioassay with Chromobacterium violaceum CV026 and the signaling molecule N- hexanoyl-L-homoserine lactone. All the compounds were subjected for ADME predictions by computational method.

Makale detayları

Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Yazarlar:

Sevil Şenkardeş | Merve Eylül Kıymacı | Ş.güniz Küçükgüzel

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.135-141

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347806

pISSN:

2630-6344

Sulfonyl hydrazone

hydrazide

MIC

antibacterial activity

quorum sensing

Sayı

Makale detayları

Synthesis, structural elucidation and biological activities of some novel sulfonyl hydrazones as antibacterial agents

Yazarlar: Sevil Şenkardeş | Merve Eylül Kıymacı | Ş.güniz Küçükgüzel

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.25 Issue 2, pp.135-141

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347806

pISSN: 2630-6344

Sulfonyl hydrazone

hydrazide

MIC

antibacterial activity

quorum sensing

Sayı

Yazarlar:

Sevil Şenkardeş | Merve Eylül Kıymacı | Ş.güniz Küçükgüzel

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.135-141

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347806

pISSN:

2630-6344