Glutathione peroxidase-lowering effects of the mangosteen pericarp extract on CCl4- induced hepatic injury in rats

Hertina SİLABAN; Berna ELYA; Mohamad SADİKİN

Makale detayları

Glutathione peroxidase-lowering effects of the mangosteen pericarp extract on CCl4- induced hepatic injury in rats

Yazarlar:

Hertina SİLABAN | Berna ELYA | Mohamad SADİKİN

Yayıncı:

Inonu University

Dergi:

Medicine Science 2016 Vol.5 Issue 3, pp.809-812

Belge Tipi:

Makale

Yayın Tarihi:

9/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000827569

Sıklık:

Üç Aylık

eISSN:

2147-0634

pISSN:

2147-0634

Özet:

 

This study aimed to investigate whether an ethanolic extract of Garcinia mangostana pericarp is able to modulate the glutathione peroxidase and glutathione system in the liver of CCl4-induced hepatic injury. Thirty one male Sprague Dawley rats were divided into five groups, including control (untreated) group; CCl4 group (at dose 0.55 mg/kg body weight dissolved in coconut oil, at day eight); EEGM group (at doses 900; 1080; and 1296 mg/kg body weight/day for eight days then received CCl4 at dose 0.55 mg/kg body weight dissolved in coconut oil). Glutathione peroxidase and GSH/GSSH ratio were assayed by colorimetric method. The level of GPx was insignificantly lower in the CCl4 group compared to the untreated control group (P > 0.05). Out of the 900 mg/kg BW, 1080 mg/kg BW, and 1296 mg/kg BW doses of Garcinia mangostana extract, only the two highest doses significantly decreased in GPx level compared to the CCl4 group or untreated control group (P  0.05). Mangosteen pericarp extract decrease the activity of glutathione peroxidase liver on CCl4-induced hepatic injury of rats.

Makale detayları

Glutathione peroxidase-lowering effects of the mangosteen pericarp extract on CCl4- induced hepatic injury in rats

Yazarlar: Hertina SİLABAN | Berna ELYA | Mohamad SADİKİN

Yayıncı: Inonu University

Dergi: Medicine Science 2016 Vol.5 Issue 3, pp.809-812

Belge Tipi: Makale

Yayın Tarihi: 9/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000827569

Sıklık: Üç Aylık

eISSN: 2147-0634

pISSN: 2147-0634

Sayı

Yazarlar:

Hertina SİLABAN | Berna ELYA | Mohamad SADİKİN

Yayıncı:

Inonu University

Dergi:

Medicine Science 2016 Vol.5 Issue 3, pp.809-812

Belge Tipi:

Makale

Yayın Tarihi:

9/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000827569

Sıklık:

Üç Aylık

eISSN:

2147-0634

pISSN:

2147-0634