The protective effect of N-acetylcysteine amide against paraquat-induced   neurotoxicity

Burhan ATEŞ; Nigar VARDI; Hakan PARLAKPINAR; Merve Gökşin KARAASLAN; İsmet YILMAZ; Nuran ERCAL

Makale detayları

The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity

Yazarlar:

Burhan ATEŞ | Nigar VARDI | Hakan PARLAKPINAR | Merve Gökşin KARAASLAN | İsmet YILMAZ | Nuran ERCAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 1, pp.39-49

Belge Tipi:

Makale

Yayın Tarihi:

1/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000725841

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

N-acetylcysteine amide (NACA) is a new antioxidant molecule with powerful   radical scavenging properties. The aim of this study was to investigate   neuroprotective effects of NACA against paraquat (PQ) toxicity in the   midbrains of rats by using motor coordination tests and biochemical   and histological analysis. Thirty adult Wistar albino rats were divided into   three groups: Group 1: control (n = 10), Group 2: PQ (10 mg/kg) (n = 10),   and Group 3: PQ (10 mg/kg) +++ NACA (100 mg/kg) (n = 10). NACA was   administrated intraperitoneally 30 min before PQ injection. Performance was   measured for a period of 28 days. The rotarod and accelerod tests were   performed prior to and after the experimental period. After the experimental   period, rats were sacrificed and midbrain tissues were removed. According to   biochemical data, malondialdehyde levels exhibited a significant increase (P   $.

Makale detayları

The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity

Yazarlar: Burhan ATEŞ | Nigar VARDI | Hakan PARLAKPINAR | Merve Gökşin KARAASLAN | İsmet YILMAZ | Nuran ERCAL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2019 Vol.43 Issue 1, pp.39-49

Belge Tipi: Makale

Yayın Tarihi: 1/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000725841

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Burhan ATEŞ | Nigar VARDI | Hakan PARLAKPINAR | Merve Gökşin KARAASLAN | İsmet YILMAZ | Nuran ERCAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 1, pp.39-49

Belge Tipi:

Makale

Yayın Tarihi:

1/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000725841

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527