Histological and Immunohistochemical Insights into the Neuroprotective Effects of Ibresartan on Lipopolysaccharide-Induced Neuroinflammation

Mehtap Savran; Nursel Hasseyid; Orhan İmeci; Özlem Özmen

Makale detayları

Histological and Immunohistochemical Insights into the Neuroprotective Effects of Ibresartan on Lipopolysaccharide-Induced Neuroinflammation

Yazarlar:

Mehtap Savran | Nursel Hasseyid | Orhan İmeci | Özlem Özmen

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

General Practice

Dergi:

Mehmet Akif Ersoy University Journal of Health Sciences Institute Vol.13 Issue 2, pp.29-37

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357210

pISSN:

2148-2837

Anahtar kelimeler:

Özet:

 Neuroinflammation is a key contributor to the development of various neurological and psychiatric disorders. Irbesartan IRB, a selective angiotensin receptor blocker, has demonstrated protective properties in multiple organ systems. This study investigates the potential neuroprotective effect of IRB against lipopolysaccharide LPS-induced neuroinflammation. Twenty-four male Wistar Albino rats were randomly assigned into three groups: control, LPS-treated 5 mgkg, and LPSIRB-treated IRB 3 mgkg. All drugs were given intraperitoneally. One hour after the LPS injection, the IRB group received the treatment. Six hours post-LPS administration, animals were sacrificed, and tissues were gathered for hematoxylin-eosin and immunostaining assessments. Caspase-3 and tumor necrosis factor-alpha levels were analyzed. LPS exposure led to notable pathological changes, including vascular congestion, edema, infiltration of neutrophils, micro hemorrhages, and neuronal degeneration in the examined brain regions. Immunohistochemistry revealed a marked elevation in apoptotic and inflammatory marker expression levels in the LPS group. Treatment with IRB significantly reduced both the histopathological damage and the expression of these inflammatory and apoptotic markers. IRB alleviated the detrimental effects of LPS-induced neuroinflammation in the rat brain, supporting its potential as a neuroprotective agent. Further studies are required to determine its efficacy across varying dosages and administration protocols.

 Neuroinflammation is a key contributor to the development of various neurological and psychiatric disorders. Irbesartan IRB, a selective angiotensin receptor blocker, has demonstrated protective properties in multiple organ systems. This study investigates the potential neuroprotective effect of IRB against lipopolysaccharide LPS-induced neuroinflammation. Twenty-four male Wistar Albino rats were randomly assigned into three groups: control, LPS-treated 5 mgkg, and LPSIRB-treated IRB 3 mgkg. All drugs were given intraperitoneally. One hour after the LPS injection, the IRB group received the treatment. Six hours post-LPS administration, animals were sacrificed, and tissues were gathered for hematoxylin-eosin and immunostaining assessments. Caspase-3 and tumor necrosis factor-alpha levels were analyzed. LPS exposure led to notable pathological changes, including vascular congestion, edema, infiltration of neutrophils, micro hemorrhages, and neuronal degeneration in the examined brain regions. Immunohistochemistry revealed a marked elevation in apoptotic and inflammatory marker expression levels in the LPS group. Treatment with IRB significantly reduced both the histopathological damage and the expression of these inflammatory and apoptotic markers. IRB alleviated the detrimental effects of LPS-induced neuroinflammation in the rat brain, supporting its potential as a neuroprotective agent. Further studies are required to determine its efficacy across varying dosages and administration protocols.

 Neuroinflammation is a key contributor to the development of various neurological and psychiatric disorders. Irbesartan IRB, a selective angiotensin receptor blocker, has demonstrated protective properties in multiple organ systems. This study investigates the potential neuroprotective effect of IRB against lipopolysaccharide LPS-induced neuroinflammation. Twenty-four male Wistar Albino rats were randomly assigned into three groups: control, LPS-treated 5 mgkg, and LPSIRB-treated IRB 3 mgkg. All drugs were given intraperitoneally. One hour after the LPS injection, the IRB group received the treatment. Six hours post-LPS administration, animals were sacrificed, and tissues were gathered for hematoxylin-eosin and immunostaining assessments. Caspase-3 and tumor necrosis factor-alpha levels were analyzed. LPS exposure led to notable pathological changes, including vascular congestion, edema, infiltration of neutrophils, micro hemorrhages, and neuronal degeneration in the examined brain regions. Immunohistochemistry revealed a marked elevation in apoptotic and inflammatory marker expression levels in the LPS group. Treatment with IRB significantly reduced both the histopathological damage and the expression of these inflammatory and apoptotic markers. IRB alleviated the detrimental effects of LPS-induced neuroinflammation in the rat brain, supporting its potential as a neuroprotective agent. Further studies are required to determine its efficacy across varying dosages and administration protocols.

 Neuroinflammation is a key contributor to the development of various neurological and psychiatric disorders. Irbesartan IRB, a selective angiotensin receptor blocker, has demonstrated protective properties in multiple organ systems. This study investigates the potential neuroprotective effect of IRB against lipopolysaccharide LPS-induced neuroinflammation. Twenty-four male Wistar Albino rats were randomly assigned into three groups: control, LPS-treated 5 mgkg, and LPSIRB-treated IRB 3 mgkg. All drugs were given intraperitoneally. One hour after the LPS injection, the IRB group received the treatment. Six hours post-LPS administration, animals were sacrificed, and tissues were gathered for hematoxylin-eosin and immunostaining assessments. Caspase-3 and tumor necrosis factor-alpha levels were analyzed. LPS exposure led to notable pathological changes, including vascular congestion, edema, infiltration of neutrophils, micro hemorrhages, and neuronal degeneration in the examined brain regions. Immunohistochemistry revealed a marked elevation in apoptotic and inflammatory marker expression levels in the LPS group. Treatment with IRB significantly reduced both the histopathological damage and the expression of these inflammatory and apoptotic markers. IRB alleviated the detrimental effects of LPS-induced neuroinflammation in the rat brain, supporting its potential as a neuroprotective agent. Further studies are required to determine its efficacy across varying dosages and administration protocols.

Makale detayları

Histological and Immunohistochemical Insights into the Neuroprotective Effects of Ibresartan on Lipopolysaccharide-Induced Neuroinflammation

Yazarlar:

Mehtap Savran | Nursel Hasseyid | Orhan İmeci | Özlem Özmen

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

General Practice

Dergi:

Mehmet Akif Ersoy University Journal of Health Sciences Institute Vol.13 Issue 2, pp.29-37

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357210

pISSN:

2148-2837

Apoptosis

Angiotensin receptor blocker

Endotoxin

Neuroinflammation

Tissue protection

Sayı

Makale detayları

Histological and Immunohistochemical Insights into the Neuroprotective Effects of Ibresartan on Lipopolysaccharide-Induced Neuroinflammation

Yazarlar: Mehtap Savran | Nursel Hasseyid | Orhan İmeci | Özlem Özmen

Yayıncı: Burdur Mehmet Akif Ersoy University

Ana Başlıklar: General Practice

Dergi: Mehmet Akif Ersoy University Journal of Health Sciences Institute Vol.13 Issue 2, pp.29-37

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357210

pISSN: 2148-2837

Apoptosis

Angiotensin receptor blocker

Endotoxin

Neuroinflammation

Tissue protection

Sayı

Yazarlar:

Mehtap Savran | Nursel Hasseyid | Orhan İmeci | Özlem Özmen

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

General Practice

Dergi:

Mehmet Akif Ersoy University Journal of Health Sciences Institute Vol.13 Issue 2, pp.29-37

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357210

pISSN:

2148-2837