Novel Green Method for the Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations

Ghufran A. Alhammadi; Lamya A. Sarsam

Makale detayları

Novel Green Method for the Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations

Yazarlar:

Ghufran A. Alhammadi | Lamya A. Sarsam

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Chemistry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.10 Issue 1, pp.193-204

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281452

pISSN:

2149-0120

Anahtar kelimeler:

Özet:

 A less environmentally harmful reagent, 2-tert-Butyl-4-methoxyphenol BHA, is used to evaluate Metoclopramide hydrochloride MCP.H by simple, rapid, sensitive, accurate and precise spectrophotometric method, through azo coupling reaction between metoclopramide hydrochloride medicine and its pharmaceutical preparation by utilizing BHA as a reagent, MCP.H azo-dye formed shows the higher absorption peak at 504 nm. Absorbance- concentration relation is linear over the range from 20 to 280 µg  5 mL, i.e. 4-56 ppm with a good sensitivity molar absorptivity 0.26x104 L.mol-1. cm-1; good precision RSD better than 0.844  and high accuracy relative error less than  0.4, Sandells sensitivity index is -0.1293 µg.cm-2, the calculated limit of detection LOD is 0.0658 µgmL and the evaluated limit of quantitation LOQ is 0.2193 µgmL. The application has had successful results for the assay of metoclopramide hydrochloride in dosage forms of tablets and injection.

 A less environmentally harmful reagent, 2-tert-Butyl-4-methoxyphenol BHA, is used to evaluate Metoclopramide hydrochloride MCP.H by simple, rapid, sensitive, accurate and precise spectrophotometric method, through azo coupling reaction between metoclopramide hydrochloride medicine and its pharmaceutical preparation by utilizing BHA as a reagent, MCP.H azo-dye formed shows the higher absorption peak at 504 nm. Absorbance- concentration relation is linear over the range from 20 to 280 µg  5 mL, i.e. 4-56 ppm with a good sensitivity molar absorptivity 0.26x104 L.mol-1. cm-1; good precision RSD better than 0.844  and high accuracy relative error less than  0.4, Sandells sensitivity index is -0.1293 µg.cm-2, the calculated limit of detection LOD is 0.0658 µgmL and the evaluated limit of quantitation LOQ is 0.2193 µgmL. The application has had successful results for the assay of metoclopramide hydrochloride in dosage forms of tablets and injection.

 A less environmentally harmful reagent, 2-tert-Butyl-4-methoxyphenol BHA, is used to evaluate Metoclopramide hydrochloride MCP.H by simple, rapid, sensitive, accurate and precise spectrophotometric method, through azo coupling reaction between metoclopramide hydrochloride medicine and its pharmaceutical preparation by utilizing BHA as a reagent, MCP.H azo-dye formed shows the higher absorption peak at 504 nm. Absorbance- concentration relation is linear over the range from 20 to 280 µg  5 mL, i.e. 4-56 ppm with a good sensitivity molar absorptivity 0.26x104 L.mol-1. cm-1; good precision RSD better than 0.844  and high accuracy relative error less than  0.4, Sandells sensitivity index is -0.1293 µg.cm-2, the calculated limit of detection LOD is 0.0658 µgmL and the evaluated limit of quantitation LOQ is 0.2193 µgmL. The application has had successful results for the assay of metoclopramide hydrochloride in dosage forms of tablets and injection.

 A less environmentally harmful reagent, 2-tert-Butyl-4-methoxyphenol BHA, is used to evaluate Metoclopramide hydrochloride MCP.H by simple, rapid, sensitive, accurate and precise spectrophotometric method, through azo coupling reaction between metoclopramide hydrochloride medicine and its pharmaceutical preparation by utilizing BHA as a reagent, MCP.H azo-dye formed shows the higher absorption peak at 504 nm. Absorbance- concentration relation is linear over the range from 20 to 280 µg  5 mL, i.e. 4-56 ppm with a good sensitivity molar absorptivity 0.26x104 L.mol-1. cm-1; good precision RSD better than 0.844  and high accuracy relative error less than  0.4, Sandells sensitivity index is -0.1293 µg.cm-2, the calculated limit of detection LOD is 0.0658 µgmL and the evaluated limit of quantitation LOQ is 0.2193 µgmL. The application has had successful results for the assay of metoclopramide hydrochloride in dosage forms of tablets and injection.

Makale detayları

Novel Green Method for the Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations

Yazarlar:

Ghufran A. Alhammadi | Lamya A. Sarsam

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Chemistry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.10 Issue 1, pp.193-204

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281452

pISSN:

2149-0120

butylated hydroxyanisole

metoclopramide hydrochloride

spectrophotomety

friendly environment

Sayı

Makale detayları

Novel Green Method for the Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations

Yazarlar: Ghufran A. Alhammadi | Lamya A. Sarsam

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Analytical Chemistry

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry Vol.10 Issue 1, pp.193-204

Belge Tipi: Makale

Yayın Tarihi: 2/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001281452

pISSN: 2149-0120

butylated hydroxyanisole

metoclopramide hydrochloride

spectrophotomety

friendly environment

Sayı

Yazarlar:

Ghufran A. Alhammadi | Lamya A. Sarsam

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Chemistry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.10 Issue 1, pp.193-204

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001281452

pISSN:

2149-0120