Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and   their binding interactions with bovine serum albumin using spectroscopic   techniques

Javed IQBAL; Aziz Ur REHMAN; Muhammad Athar ABBASI; Sabahat Zahra SIDDIQUI; Hira KHALID; Sabina Jhaumeer LAULLOO; Nausheen JOONDAN; Aniisah Banu TAUPASS; Shahid RASOOL; Syed Adnan Ali SHAH

Makale detayları

Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques

Yazarlar:

Javed IQBAL | Aziz Ur REHMAN | Muhammad Athar ABBASI | Sabahat Zahra SIDDIQUI | Hira KHALID | Sabina Jhaumeer LAULLOO | Nausheen JOONDAN | Aniisah Banu TAUPASS | Shahid RASOOL | Syed Adnan Ali SHAH

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 6, pp.1459-1478

Belge Tipi:

Makale

Yayın Tarihi:

11/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000725922

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized   using 11^{1}H NMR, 1313^{13}C NMR, IR, and EI-MS spectroscopic analysis. The   intermediate triazole was synthesized through a sequential   synthesis of carboxylate and carbohydrazide. The bovine serum   albumin (BSA) binding of the newly synthesized 1,2,4-triazole derivatives   was evaluated along with thermodynamics, site-selective binding, and   synchronous study. The results obtained by BSA binding as well as   thermodynamic studies justify that all the compounds show spontaneous   interaction with BSA and could be effectively distributed and eliminated   from the body. Therefore, the triazole-based analogs might be a useful   strategy for designing new drug systems.

Makale detayları

Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques

Yazarlar: Javed IQBAL | Aziz Ur REHMAN | Muhammad Athar ABBASI | Sabahat Zahra SIDDIQUI | Hira KHALID | Sabina Jhaumeer LAULLOO | Nausheen JOONDAN | Aniisah Banu TAUPASS | Shahid RASOOL | Syed Adnan Ali SHAH

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2018 Vol.42 Issue 6, pp.1459-1478

Belge Tipi: Makale

Yayın Tarihi: 11/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000725922

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Javed IQBAL | Aziz Ur REHMAN | Muhammad Athar ABBASI | Sabahat Zahra SIDDIQUI | Hira KHALID | Sabina Jhaumeer LAULLOO | Nausheen JOONDAN | Aniisah Banu TAUPASS | Shahid RASOOL | Syed Adnan Ali SHAH

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 6, pp.1459-1478

Belge Tipi:

Makale

Yayın Tarihi:

11/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000725922

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527