Evaluation of Tissue Factor -603 A/G Promoter Gene Polymorphism in Thrombotic Processes in Patients with Antiphospholipid Syndrome

Resul KAHRAMAN; Veysel HANCER; Arzu ERGEN; Bedia ÇAKMAKOĞLU; Reyhan DİZ KÜÇÜKKAYA

doi:https://doi.org/10.26650/experimed.2019.19006

Makale detayları

Evaluation of Tissue Factor -603 A/G Promoter Gene Polymorphism in Thrombotic Processes in Patients with Antiphospholipid Syndrome

Yazarlar:

Resul KAHRAMAN | Veysel HANCER | Arzu ERGEN | Bedia ÇAKMAKOĞLU | Reyhan DİZ KÜÇÜKKAYA

Yayıncı:

Istanbul University

Ana Başlıklar:

Hastalıklar

Dergi:

Experimed 2019 Vol.9 Issue 1, pp.1-6

Belge Tipi:

Makale

Yayın Tarihi:

4/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000429013

eISSN:

2667-5846

DOI:

https://doi.org/10.26650/experimed.2019.19006

Özet:

 


DOI:
10.26650/experimed.2019.19006



Objective: Major clinical manifestations of
Antiphospholipid syndrome (APS) are trombosis and thrombosis related
complications. Tissue factor (TF) serves primary initiatory of the in vivo
coagulation. TF gene expression may be induced in endothelial cells to initiate
thrombus formation. In this study, we investigated the frequency of TF 603A/G
promoter gene polymorphism in patients with antiphospholipid syndrome (APS) and
its effects on TF expression and thrombotic events.


Materials and Methods: This study included
64 patients with APS (APS patient with thrombosis arterial and venous (n=38),
antiphospholipid antibody-positive patients without thrombosis (n=26) and 44
healthy controls (HCs). Plasma TF levels and antiphospholipid antibodies were
measured by ELISA method. Lupus anticoagulant was measured by activated partial
thromboplastin time and kaolin clotting time. TF-603 A/G polymorphism was
investigated by PCR method.


Results: Our results have showed that
patients with APS, TF levels were found in patients significantly higher than
the healthy control group (p: 0.006, p<0.001, respectively). Compared
between the two patient groups, TF level was significantly higher in the
patient with thrombosis group compared to the patient without thrombosis group
(p: 0.027).









Conclusion: In this study, we suggest that
thrombotic complications observed in patients with APS are associated with
increased TF expression.

Cite this article as: Kahraman R, Hançer V,
Ergen A, Çakmakoğlu B, Diz Küçükkaya R. Evaluation of tissue factor -603 A/G
promoter gene polymorphism in thrombotic processes in patients with
antiphospholipid syndrome. Experimed 2019; 9(1): 1-6.



.

Makale detayları

Evaluation of Tissue Factor -603 A/G Promoter Gene Polymorphism in Thrombotic Processes in Patients with Antiphospholipid Syndrome

Yazarlar: Resul KAHRAMAN | Veysel HANCER | Arzu ERGEN | Bedia ÇAKMAKOĞLU | Reyhan DİZ KÜÇÜKKAYA

Yayıncı: Istanbul University

Ana Başlıklar: Hastalıklar

Dergi: Experimed 2019 Vol.9 Issue 1, pp.1-6

Belge Tipi: Makale

Yayın Tarihi: 4/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000429013

eISSN: 2667-5846

DOI: https://doi.org/10.26650/experimed.2019.19006

Sayı

Yazarlar:

Resul KAHRAMAN | Veysel HANCER | Arzu ERGEN | Bedia ÇAKMAKOĞLU | Reyhan DİZ KÜÇÜKKAYA

Yayıncı:

Istanbul University

Ana Başlıklar:

Hastalıklar

Dergi:

Experimed 2019 Vol.9 Issue 1, pp.1-6

Belge Tipi:

Makale

Yayın Tarihi:

4/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000429013

eISSN:

2667-5846

DOI:

https://doi.org/10.26650/experimed.2019.19006