Serum adenosine deaminase activity and the total antioxidant capacity of plasma in pulmonary tuberculosis and non-tuberculosis pulmonary disease

Mohammad NADERI; Mohammad HASHEMI; Ali MEHDIZADEH; Hamid MEHRABIFAR; Hamid Reza KOUHPAYEH; Hossein ANSARI; Gholamreza BAHARI; Saeid GHAVAMI

Makale detayları

Serum adenosine deaminase activity and the total antioxidant capacity of plasma in pulmonary tuberculosis and non-tuberculosis pulmonary disease

Yazarlar:

Mohammad NADERI | Mohammad HASHEMI | Ali MEHDIZADEH | Hamid MEHRABIFAR | Hamid Reza KOUHPAYEH | Hossein ANSARI | Gholamreza BAHARI | Saeid GHAVAMI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.701-706

Belge Tipi:

Makale

Yayın Tarihi:

4/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754939

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

The aim of this study was to investigate the level of serum adenosine deaminase (ADA) and the total antioxidant capacity (TAC) in pulmonary tuberculosis (PTB), non-tuberculosis pulmonary disease (non-PTB) and healthy subjects.   Materials and methods: Serum ADA activity was measured using the Giusti and Galanti method, and the total antioxidant capacity of plasma was determined by the ferric reducing ability of plasma (FRAP) test.   Results: The serum ADA levels were significantly higher (P < 0.001) in pulmonary TB (PTB, 19.78 ± 7.09 U/L), as well as in non-PTB patients (14.78 ± 4.65 U/L) when compared to healthy controls (10.02 ± 1.99 U/L). The sensitivity and specificity were found to be 71.7% and 63.3%, respectively, in distinguishing PTB from non-PTB. In distinguishing PTB from healthy subjects, the sensitivity and specificity were 87% and 93.3%, respectively. The TAC was significantly lower in PTB (485.2 ± 190.0 µM) and non-PTB patients (588.3 ± 195.8 µM), when compared to the controls (784.3 ± 190.0 µM; P < 0.001). Plasma antioxidative activity decreased in PTB and non-PTB patients when compared to the controls.  Conclusion: We concluded that serum ADA activity is not a useful test to differentiate pulmonary TB from other respiratory diseases. The TAC is low in pulmonary TB, therefore supplementation with a suitable anti-oxidant may be useful.

 

The aim of this study was to investigate the level of serum adenosine deaminase (ADA) and the total antioxidant capacity (TAC) in pulmonary tuberculosis (PTB), non-tuberculosis pulmonary disease (non-PTB) and healthy subjects.   Materials and methods: Serum ADA activity was measured using the Giusti and Galanti method, and the total antioxidant capacity of plasma was determined by the ferric reducing ability of plasma (FRAP) test.   Results: The serum ADA levels were significantly higher (P < 0.001) in pulmonary TB (PTB, 19.78 ± 7.09 U/L), as well as in non-PTB patients (14.78 ± 4.65 U/L) when compared to healthy controls (10.02 ± 1.99 U/L). The sensitivity and specificity were found to be 71.7% and 63.3%, respectively, in distinguishing PTB from non-PTB. In distinguishing PTB from healthy subjects, the sensitivity and specificity were 87% and 93.3%, respectively. The TAC was significantly lower in PTB (485.2 ± 190.0 µM) and non-PTB patients (588.3 ± 195.8 µM), when compared to the controls (784.3 ± 190.0 µM; P < 0.001). Plasma antioxidative activity decreased in PTB and non-PTB patients when compared to the controls.  Conclusion: We concluded that serum ADA activity is not a useful test to differentiate pulmonary TB from other respiratory diseases. The TAC is low in pulmonary TB, therefore supplementation with a suitable anti-oxidant may be useful.

Makale detayları

Serum adenosine deaminase activity and the total antioxidant capacity of plasma in pulmonary tuberculosis and non-tuberculosis pulmonary disease

Yazarlar:

Mohammad NADERI | Mohammad HASHEMI | Ali MEHDIZADEH | Hamid MEHRABIFAR | Hamid Reza KOUHPAYEH | Hossein ANSARI | Gholamreza BAHARI | Saeid GHAVAMI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.701-706

Belge Tipi:

Makale

Yayın Tarihi:

4/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754939

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Tuberculosis

adenosine deaminase activity

ADA

total antioxidant capacity

Sayı

Makale detayları

Serum adenosine deaminase activity and the total antioxidant capacity of plasma in pulmonary tuberculosis and non-tuberculosis pulmonary disease

Yazarlar: Mohammad NADERI | Mohammad HASHEMI | Ali MEHDIZADEH | Hamid MEHRABIFAR | Hamid Reza KOUHPAYEH | Hossein ANSARI | Gholamreza BAHARI | Saeid GHAVAMI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.701-706

Belge Tipi: Makale

Yayın Tarihi: 4/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000754939

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Tuberculosis

adenosine deaminase activity

ADA

total antioxidant capacity

Sayı

Yazarlar:

Mohammad NADERI | Mohammad HASHEMI | Ali MEHDIZADEH | Hamid MEHRABIFAR | Hamid Reza KOUHPAYEH | Hossein ANSARI | Gholamreza BAHARI | Saeid GHAVAMI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 5, pp.701-706

Belge Tipi:

Makale

Yayın Tarihi:

4/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000754939

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144