Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

Abdel-Galil El-Sayed AMR; Naglaa Abdel-Samei ABDEL-HAFEZ; Salwa Fahem MOHAMED; Mohamed Mostafa ABDALLA

Makale detayları

Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

Yazarlar:

Abdel-Galil El-Sayed AMR | Naglaa Abdel-Samei ABDEL-HAFEZ | Salwa Fahem MOHAMED | Mohamed Mostafa ABDALLA

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.421-432

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

İngilizce

Document ID (Org No.):

2000728306

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

We report herein the synthesis and antiarrhythmic activities  of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and  theino[2,3-c]pyridine derivatives fused with thiophene moiety.  Initially the acute toxicity of the compounds was assayed via the  determination of their LD50.  The antiarrhythmic activities for the  compounds were determined and all the tested compounds were found more  potent than Procaine amide\textregistered and  Lidocaine\textregistered as positive antiarrhythmic controls.

 

We report herein the synthesis and antiarrhythmic activities  of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and  theino[2,3-c]pyridine derivatives fused with thiophene moiety.  Initially the acute toxicity of the compounds was assayed via the  determination of their LD50.  The antiarrhythmic activities for the  compounds were determined and all the tested compounds were found more  potent than Procaine amide\textregistered and  Lidocaine\textregistered as positive antiarrhythmic controls.

Makale detayları

Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

Yazarlar: Abdel-Galil El-Sayed AMR | Naglaa Abdel-Samei ABDEL-HAFEZ | Salwa Fahem MOHAMED | Mohamed Mostafa ABDALLA

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.421-432

Belge Tipi: Makale

Yayın Tarihi: 2/2009

Belge Dili: İngilizce

Document ID (Org No.): 2000728306

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Abdel-Galil El-Sayed AMR | Naglaa Abdel-Samei ABDEL-HAFEZ | Salwa Fahem MOHAMED | Mohamed Mostafa ABDALLA

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.421-432

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

İngilizce

Document ID (Org No.):

2000728306

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527