Correlation between serum levels of vitamin B12 and anti-Helicobacter pyloriIgA antibodies in vitamin B12 deficient Palestinian patients

RASMI ABU HILU; OSAMA DUDEEN; SAMEER ABDULLATIF BARGHOUTHI

Makale detayları

Correlation between serum levels of vitamin B12 and anti-Helicobacter pyloriIgA antibodies in vitamin B12 deficient Palestinian patients

Yazarlar:

RASMI ABU HILU | OSAMA DUDEEN | SAMEER ABDULLATIF BARGHOUTHI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.627-633

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752692

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Background/aim: H. pylori infection and vitamin B12 (vB12) deficiency have high prevalence rates among Palestinians. It was observed that most people who suffered from vB12 deficiency were positive for H. pylori.   Materials and methods: The correlation between H. pylori infection and vB12 deficiency was investigated in a representative segment of the Palestinian population. ELISA was used to determine levels of vitamin B12 (vB12) and anti-H. pylori IgA in sera from 238 participants from Al-Khalil district (Hebron), Palestine.   Results: There was a strong negative Pearson's correlation coefficient (r = -0.45; P = 0.00001) between levels of anti-H. pylori IgA and vB12 levels in sera drawn from 238 participants (133 patients and 105 control subjects). Two important contaminating variables were identified in this study: healthy control subjects with elevated anti-H. pylori IgA titers and vB12-deficient patients testing negative for anti-H. pylori IgA antibodies. The exclusion of the sources of contamination resulted in a stronger negative correlation; r = -0.58 (P = 0.00001).  Conclusion: The study provided a good screening system that may predict vB12 deficiency before its actual manifestation. If not treated, asymptomatic subjects showing increased anti-H.pylori IgA titers (>15 NTU/mL) are likely to be at risk of developing vB12 deficiency.

 

Background/aim: H. pylori infection and vitamin B12 (vB12) deficiency have high prevalence rates among Palestinians. It was observed that most people who suffered from vB12 deficiency were positive for H. pylori.   Materials and methods: The correlation between H. pylori infection and vB12 deficiency was investigated in a representative segment of the Palestinian population. ELISA was used to determine levels of vitamin B12 (vB12) and anti-H. pylori IgA in sera from 238 participants from Al-Khalil district (Hebron), Palestine.   Results: There was a strong negative Pearson's correlation coefficient (r = -0.45; P = 0.00001) between levels of anti-H. pylori IgA and vB12 levels in sera drawn from 238 participants (133 patients and 105 control subjects). Two important contaminating variables were identified in this study: healthy control subjects with elevated anti-H. pylori IgA titers and vB12-deficient patients testing negative for anti-H. pylori IgA antibodies. The exclusion of the sources of contamination resulted in a stronger negative correlation; r = -0.58 (P = 0.00001).  Conclusion: The study provided a good screening system that may predict vB12 deficiency before its actual manifestation. If not treated, asymptomatic subjects showing increased anti-H.pylori IgA titers (>15 NTU/mL) are likely to be at risk of developing vB12 deficiency.

Makale detayları

Correlation between serum levels of vitamin B12 and anti-Helicobacter pyloriIgA antibodies in vitamin B12 deficient Palestinian patients

Yazarlar:

RASMI ABU HILU | OSAMA DUDEEN | SAMEER ABDULLATIF BARGHOUTHI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.627-633

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752692

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Helicobacter pylori

vitamin B12 deficiency

cobalamin

gastroenteritis

correlation

baseline

Sayı

Makale detayları

Correlation between serum levels of vitamin B12 and anti-Helicobacter pyloriIgA antibodies in vitamin B12 deficient Palestinian patients

Yazarlar: RASMI ABU HILU | OSAMA DUDEEN | SAMEER ABDULLATIF BARGHOUTHI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.627-633

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000752692

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Helicobacter pylori

vitamin B12 deficiency

cobalamin

gastroenteritis

correlation

baseline

Sayı

Yazarlar:

RASMI ABU HILU | OSAMA DUDEEN | SAMEER ABDULLATIF BARGHOUTHI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.627-633

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752692

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144