Development of a Sensitive Electrochemical Sensor for the Simultaneous Quantification of Acetaminophen Traces onto Carbon Paste Electrode Modified with Black Carbon and La0.6Sr0.4Co0.8Fe0.2O3 Nano-Sized Particles

Mosbah Ferkhi; Ebru Kuyumcu Savan

Makale detayları

Development of a Sensitive Electrochemical Sensor for the Simultaneous Quantification of Acetaminophen Traces onto Carbon Paste Electrode Modified with Black Carbon and La0.6Sr0.4Co0.8Fe0.2O3 Nano-Sized Particles

Yazarlar:

Mosbah Ferkhi | Ebru Kuyumcu Savan

Yayıncı:

Inonu University

Ana Başlıklar:

Electroanalytical Chemistry

Dergi:

Anatolian Journal of Pharmaceutical Sciences Vol.4 Issue 1, pp.27-47

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343932

pISSN:

2980-0463

Anahtar kelimeler:

Özet:

 Recently, the development of an advanced electrochemical sensor has received tremendous attention in the field of drug monitoring. The La0.6Sr0.4Co0.8Fe0.2O3 LSCF nano-sized oxides were synthesized by a simple sol-gel citrate method, modified with black carbon BC and prepared as a carbon paste electrode CPE for the simultaneous determination of paracetamol PCM traces presence in PBS electrolyte through cyclic voltammetry CV, differential pulse voltammetry DPV and electrochemical impedance spectroscopy EIS as sensing techniques. X-ray diffraction XRD, scanning electron microscopy SEM, and Ferrocyanide test were characterization techniques. The calculated crystallite size d, was found to be 208.317 nm by XRD and 65.05 nm by SEM analysis. In conclusion, the modified prepared sensor LSCFBCCPE demonstrates a very satisfactory response, sensitivity, and selectivity towards PCM molecules compared with literature with a very low detection limit of 36 nM, high sensitivity of 75 µA.µM1.cm2, with a wide linear range from 0.1 µM to 180 µM by DPV technique. The modified LSCFBCCPE sensor demonstrated excellent results in the real pharmaceutical sample with a very good recovery of 94.56  and a satisfactory relative standard deviation of 3.26 .

 Recently, the development of an advanced electrochemical sensor has received tremendous attention in the field of drug monitoring. The La0.6Sr0.4Co0.8Fe0.2O3 LSCF nano-sized oxides were synthesized by a simple sol-gel citrate method, modified with black carbon BC and prepared as a carbon paste electrode CPE for the simultaneous determination of paracetamol PCM traces presence in PBS electrolyte through cyclic voltammetry CV, differential pulse voltammetry DPV and electrochemical impedance spectroscopy EIS as sensing techniques. X-ray diffraction XRD, scanning electron microscopy SEM, and Ferrocyanide test were characterization techniques. The calculated crystallite size d, was found to be 208.317 nm by XRD and 65.05 nm by SEM analysis. In conclusion, the modified prepared sensor LSCFBCCPE demonstrates a very satisfactory response, sensitivity, and selectivity towards PCM molecules compared with literature with a very low detection limit of 36 nM, high sensitivity of 75 µA.µM1.cm2, with a wide linear range from 0.1 µM to 180 µM by DPV technique. The modified LSCFBCCPE sensor demonstrated excellent results in the real pharmaceutical sample with a very good recovery of 94.56  and a satisfactory relative standard deviation of 3.26 .

 Recently, the development of an advanced electrochemical sensor has received tremendous attention in the field of drug monitoring. The La0.6Sr0.4Co0.8Fe0.2O3 LSCF nano-sized oxides were synthesized by a simple sol-gel citrate method, modified with black carbon BC and prepared as a carbon paste electrode CPE for the simultaneous determination of paracetamol PCM traces presence in PBS electrolyte through cyclic voltammetry CV, differential pulse voltammetry DPV and electrochemical impedance spectroscopy EIS as sensing techniques. X-ray diffraction XRD, scanning electron microscopy SEM, and Ferrocyanide test were characterization techniques. The calculated crystallite size d, was found to be 208.317 nm by XRD and 65.05 nm by SEM analysis. In conclusion, the modified prepared sensor LSCFBCCPE demonstrates a very satisfactory response, sensitivity, and selectivity towards PCM molecules compared with literature with a very low detection limit of 36 nM, high sensitivity of 75 µA.µM1.cm2, with a wide linear range from 0.1 µM to 180 µM by DPV technique. The modified LSCFBCCPE sensor demonstrated excellent results in the real pharmaceutical sample with a very good recovery of 94.56  and a satisfactory relative standard deviation of 3.26 .

 Recently, the development of an advanced electrochemical sensor has received tremendous attention in the field of drug monitoring. The La0.6Sr0.4Co0.8Fe0.2O3 LSCF nano-sized oxides were synthesized by a simple sol-gel citrate method, modified with black carbon BC and prepared as a carbon paste electrode CPE for the simultaneous determination of paracetamol PCM traces presence in PBS electrolyte through cyclic voltammetry CV, differential pulse voltammetry DPV and electrochemical impedance spectroscopy EIS as sensing techniques. X-ray diffraction XRD, scanning electron microscopy SEM, and Ferrocyanide test were characterization techniques. The calculated crystallite size d, was found to be 208.317 nm by XRD and 65.05 nm by SEM analysis. In conclusion, the modified prepared sensor LSCFBCCPE demonstrates a very satisfactory response, sensitivity, and selectivity towards PCM molecules compared with literature with a very low detection limit of 36 nM, high sensitivity of 75 µA.µM1.cm2, with a wide linear range from 0.1 µM to 180 µM by DPV technique. The modified LSCFBCCPE sensor demonstrated excellent results in the real pharmaceutical sample with a very good recovery of 94.56  and a satisfactory relative standard deviation of 3.26 .

Makale detayları

Development of a Sensitive Electrochemical Sensor for the Simultaneous Quantification of Acetaminophen Traces onto Carbon Paste Electrode Modified with Black Carbon and La0.6Sr0.4Co0.8Fe0.2O3 Nano-Sized Particles

Yazarlar:

Mosbah Ferkhi | Ebru Kuyumcu Savan

Yayıncı:

Inonu University

Ana Başlıklar:

Electroanalytical Chemistry

Dergi:

Anatolian Journal of Pharmaceutical Sciences Vol.4 Issue 1, pp.27-47

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343932

pISSN:

2980-0463

Sensor

Nanoparticles

Black carbon

Paracetamol

Cyclic voltammetry

Differential pulse voltammetry.

Sayı

Makale detayları

Development of a Sensitive Electrochemical Sensor for the Simultaneous Quantification of Acetaminophen Traces onto Carbon Paste Electrode Modified with Black Carbon and La0.6Sr0.4Co0.8Fe0.2O3 Nano-Sized Particles

Yazarlar: Mosbah Ferkhi | Ebru Kuyumcu Savan

Yayıncı: Inonu University

Ana Başlıklar: Electroanalytical Chemistry

Dergi: Anatolian Journal of Pharmaceutical Sciences Vol.4 Issue 1, pp.27-47

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001343932

pISSN: 2980-0463

Sensor

Nanoparticles

Black carbon

Paracetamol

Cyclic voltammetry

Differential pulse voltammetry.

Sayı

Yazarlar:

Mosbah Ferkhi | Ebru Kuyumcu Savan

Yayıncı:

Inonu University

Ana Başlıklar:

Electroanalytical Chemistry

Dergi:

Anatolian Journal of Pharmaceutical Sciences Vol.4 Issue 1, pp.27-47

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001343932

pISSN:

2980-0463