NEW NEOADJUVANT TREATMENT STRATEGIES FOR GASTRIC AND GASTROESOPHAGEAL JUNCTION CANCERS

Serdar Turhal; Howard Bruckner

Makale detayları

NEW NEOADJUVANT TREATMENT STRATEGIES FOR GASTRIC AND GASTROESOPHAGEAL JUNCTION CANCERS

Yazarlar:

Serdar Turhal | Howard Bruckner

Yayıncı:

Marmara University

Dergi:

Marmara Medical Journal 1999 Vol.12 Issue 1, pp.20-24

Belge Tipi:

Makale

Yayın Tarihi:

12/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000546771

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941

Özet:

 


Objective: The feasibility of neoadjuvantchemotherapy for clinically unresectable gastric and gastroesophageal (GE) junction cancers.Methods: Eleven patients with gastric and GE junction cancers underwent preoperative combined modality chemo and radiotherapy and a subsequent attempt for surgical resection.Results: Combined modality periadjuvant therapies downsized 9 of 11 T3-4 gastric and gastroesophageal junction cancers and produced 4 pathologically proven complete remissions. Treatment appeared to convert lymph nodes to a cancer free status for 7 of 11 patients. After treatment, exploratory surgery found that 3 patients had only minute foci of occult metastatic disease. The quality of the responses was underestimated by both endoscopic ultrasound and CT scans. Responses were sometimes only achieved after 2-3 months of therapy.Conclusion: Combined modality therapydemonstrates the feasibility of a flexible multistep approach to neoadjuvant therapy incorporating new drugs such as methotrexate and hydroxyurea in addition to fluorouracil and cisplatin. Long delays in surgery (gastrectomy) appear to be safe in the context of combined modality therapy. Median survival exceeds 2 years. The experience suggests new early end points for evaluation of neoadjuvant treatments: quality of life, quality of lymph node sterilization and extent of required gastrectomy in comparison to standard surgery.Key Words: Neoadjuvant, Gastric cancer, Gastroesophageal cancer, Combined modality treatment

.

Makale detayları

NEW NEOADJUVANT TREATMENT STRATEGIES FOR GASTRIC AND GASTROESOPHAGEAL JUNCTION CANCERS

Yazarlar: Serdar Turhal | Howard Bruckner

Yayıncı: Marmara University

Dergi: Marmara Medical Journal 1999 Vol.12 Issue 1, pp.20-24

Belge Tipi: Makale

Yayın Tarihi: 12/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000546771

Sıklık: Aylık

eISSN: 1309-9469

pISSN: 1019-1941

Sayı

Yazarlar:

Serdar Turhal | Howard Bruckner

Yayıncı:

Marmara University

Dergi:

Marmara Medical Journal 1999 Vol.12 Issue 1, pp.20-24

Belge Tipi:

Makale

Yayın Tarihi:

12/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000546771

Sıklık:

Aylık

eISSN:

1309-9469

pISSN:

1019-1941